Cryoem structure of go-coupled 5-HT5AR in complex with methylergometrine

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• H8D · (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7UM7 · CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine · the same entry in another collection · chain E against E, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain C against A, TM-score 0.99
• P47898 · AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 5A (P47898) · a predicted model of the same protein · chain A against A, TM-score 0.94
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain D against A, TM-score 0.85

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P47898
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Elsewhere: RCSB PDB 7UM7 · PDBe 7UM7 · UniProt P47898 · UniProt P62873 · UniProt P59768