UniProt P47898
5-hydroxytryptamine receptor 5A (P47898)
5-hydroxytryptamine receptor 5A (UniProt P47898): 9 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P47898
- Protein
- 5-hydroxytryptamine receptor 5A
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 17 · 5 records with a druggable one
Structures
10 records of P47898 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7UM4 | Crystal structure of inactive 5-HT5AR in complex with AS2674723 | x-ray diffraction | A | NN6 | 2 (best 0.75) |
| 7UM4 | Crystal structure of inactive 5-HT5AR in complex with AS2674723 | x-ray diffraction | A | NN6 | — |
| 7UM5 | CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT | electron microscopy | A | 8K3 | 4 (best 0.78) |
| 7UM5 | Cryoem structure of go-coupled 5-HT5AR in complex with 5-ct | electron microscopy | A | 8K3 | — |
| 7UM6 | CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride | electron microscopy | A | H8G | 4 (best 0.77) |
| 7UM6 | Cryoem structure of go-coupled 5-HT5AR in complex with lisuride | electron microscopy | A | H8G | — |
| 7UM7 | CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine | electron microscopy | A | H8D | 4 (best 0.73) |
| 7UM7 | Cryoem structure of go-coupled 5-HT5AR in complex with methylergometrine | electron microscopy | A | H8D | — |
| 7X5H | Serotonin 5A (5-HT5A) receptor-Gi protein complex | electron microscopy | R | 8K3 | 3 (best 0.77) |
| P47898 | AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 5A (P47898) | predicted | A | — | — |
Ligands
- 8K3 · 3-(2-azanylethyl)-1H-indole-5-carboxamide · in 3 records
- H8D · (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide · in 2 records
- H8G · N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea · in 2 records
- NN6 · ~{N}-[azanyl(azanylidene)methylidene]-5-fluoranyl-8-[2, 4,6-tris(fluoranyl)phenyl]-3,4-dihydro-1~{H}-isoquinoline-2-carboxamide · in 2 records
Experiment against prediction
- 7X5H chain R against the predicted model P47898: TM-score 0.95, RMSD 1.55 Å
- 7UM5 chain A against the predicted model P47898: TM-score 0.95, RMSD 1.56 Å
- 7UM5 chain A against the predicted model P47898: TM-score 0.95, RMSD 1.56 Å
- 7UM7 chain A against the predicted model P47898: TM-score 0.94, RMSD 1.57 Å
- 7UM7 chain A against the predicted model P47898: TM-score 0.94, RMSD 1.57 Å
- 7UM6 chain A against the predicted model P47898: TM-score 0.94, RMSD 1.71 Å
- 7UM6 chain A against the predicted model P47898: TM-score 0.94, RMSD 1.71 Å
- 7UM4 chain A against the predicted model P47898: TM-score 0.90, RMSD 2.30 Å
- 7UM4 chain A against the predicted model P47898: TM-score 0.90, RMSD 2.30 Å
- 7X5H chain R against the predicted model P0ABE7: TM-score 0.29, RMSD 4.48 Å
Elsewhere
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