Research workbench
Mvm nes mutant NM2 in complex with CRM1-ran-RANBP1
Analyse Mvm nes mutant NM2 in complex with CRM1-ran-RANBP1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6A3A
- Type
- protein
- Length
- 1,352 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP-binding nuclear protein ran; Ran-specific GTPase-activating protein 1; Exportin-1…
- UniProt
- P62826, P41920, P30822
- Ligands
- GTP, MG, NA
- Pockets
- 14 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 65% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTP-binding nuclear protein ran | protein | 210 | 32% helix, 22% strand | P62826 |
| B | Ran-specific GTPase-activating protein 1 | protein | 129 | 14% helix, 47% strand | P41920 |
| C | Exportin-1 | protein | 996 | 79% helix, 0% strand | P30822 |
| D | Mvm nes mutant NM2 | protein | 17 | 53% helix, 0% strand | — |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- NA · Sodium ion · metal · chains C
- EDO · 1,2-ethanediol · additive · chains A
- GOL · Glycerol · additive · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 902 | 0.86 | 0.87 | 110 | EDO |
| 2 | 757 | 0.68 | 0.76 | 60 | empty |
| 3 | 119 | 0.66 | 0.89 | 30 | GTP, MG |
| 4 | 77 | 0.64 | 0.92 | 25 | empty |
| 5 | 411 | 0.62 | 0.77 | 44 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2114 Ų buried · 34 hydrogen bonds · protein-protein
- A–C · 2046 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 971 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 185 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6A3A · MVM NES mutant Nm2 in complex with CRM1-Ran-RanBP1 · the same entry in another collection · chain C against C, TM-score 1.00
- P30822 · AlphaFold monomer V2.0 prediction for exportin-1 (P30822) · a predicted model of the same protein · chain C against A, TM-score 0.98
- P41920 · AlphaFold monomer V2.0 prediction for ran-specific GTPase-activating protein 1 (P41920) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62826
- Every structure of UniProt P41920
- Every structure of UniProt P30822
- Elsewhere: RCSB PDB 6A3A · PDBe 6A3A · UniProt P62826 · UniProt P41920 · UniProt P30822
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