Crystal structure of thermus thermophilus transcription initiation complex with gpa and pseudouridimycin (pum)

Structure

x-ray diffraction · 9 distinct chains.

Ligands and binding sites

• PUM · (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2, 3,4-tetrahydropyrimidin-5-yl)-D-ribitol · ligand · chains C, D, G, I
• MG · Magnesium ion · metal · 6 copies · chains A, C, B, D, I, F, H
• ZN · Zinc ion · metal · 2 copies · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5X21 · Crystal structure of Thermus thermophilus transcription initiation complex with GpA and… · the same entry in another collection · chain H against H, TM-score 1.00
• Q9Z9H6 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (Q9Z9H6) · a predicted model of the same protein · chain A against A, TM-score 0.97
• Q72L95 · AlphaFold monomer V2.0 prediction for RNA polymerase sigma factor siga (Q72L95) · a predicted model of the same protein · chain F against A, TM-score 0.97
• Q72ID6 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit omega (Q72ID6) · a predicted model of the same protein · chain E against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Z9H6
• Every structure of UniProt Q8RQE9
• Every structure of UniProt Q8RQE8
• Every structure of UniProt Q72ID6
• Every structure of UniProt Q72L95
• Elsewhere: RCSB PDB 5X21 · PDBe 5X21 · UniProt Q9Z9H6 · UniProt Q8RQE9 · UniProt Q8RQE8 · UniProt Q72ID6 · UniProt Q72L95