UniProt Q9Z9H6
DNA-directed RNA polymerase subunit alpha (Q9Z9H6)
DNA-directed RNA polymerase subunit alpha (UniProt Q9Z9H6), EC 2.7.7.6: 40 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9Z9H6
- Protein
- DNA-directed RNA polymerase subunit alpha
- EC
- 2.7.7.6
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 15 · 2 records with a druggable one
Structures
41 records of Q9Z9H6 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DOQ | The C-terminal domain of the RNA polymerase alpha subunit from thermus thermophilus | solution nmr | A | — | — |
| 1DOQ | The C-terminal domain of the RNA polymerase alpha subunit from thermus thermophilus | solution nmr | A | — | — |
| 1IW7 | Crystal structure of the RNA polymerase holoenzyme from Thermus thermophilus at 2.6A resolution | x-ray diffraction | A, B, K, L | — | — |
| 1IW7 | Crystal structure of the RNA polymerase holoenzyme from thermus thermophilus at 2.6A resolution | x-ray diffraction | A, B, K, L | — | — |
| 1SMY | Structural basis for transcription regulation by alarmone ppGpp | x-ray diffraction | A, B, K, L | — | — |
| 1SMY | Structural basis for transcription regulation by alarmone ppgpp | x-ray diffraction | A, B, K, L | — | — |
| 2A68 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | A, B, K, L | — | — |
| 2A68 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | A, B, K, L | — | — |
| 2A69 | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | A, B, K, L | — | — |
| 2A69 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | A, B, K, L | — | — |
| 2BE5 | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor… | x-ray diffraction | A, B, K, L | — | — |
| 2BE5 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with inhibitor… | x-ray diffraction | A, B, K, L | — | — |
| 2PPB | Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the ntp substrate… | x-ray diffraction | A, B, K, L | — | — |
| 2PPB | Crystal structure of the T. thermophilus rnap polymerase elongation complex with the ntp substrate… | x-ray diffraction | A, B, K, L | — | — |
| 3EQL | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | A, B, K, L | — | — |
| 3EQL | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | A, B, K, L | — | — |
| 4Q4Z | Thermus thermophilus RNA polymerase de novo transcription initiation complex | x-ray diffraction | A, B | — | — |
| 4Q4Z | Thermus thermophilus RNA polymerase de novo transcription initiation complex | x-ray diffraction | A, B | — | — |
| 4Q5S | Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA | x-ray diffraction | A, B | — | — |
| 4Q5S | Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA | x-ray diffraction | A, B | — | — |
| 5D4C | Crystal structure of thermus thermophilus product complex for transcription initiation with ATP and… | x-ray diffraction | A, B, K, L | — | — |
| 5D4D | Crystal structure of thermus thermophilus product complex for transcription initiation with NAD and… | x-ray diffraction | A, B, K, L | — | — |
| 5D4E | Crystal structure of thermus thermophilus product complex for transcription initiation with… | x-ray diffraction | A, B, K, L | — | — |
| 5E17 | T. thermophilus transcription initiation complex having a RRR discriminator sequence and a… | x-ray diffraction | A, B | MG | 6 (best 0.86) |
| 5E17 | T. thermophilus transcription initiation complex having a rrr discriminator sequence and a… | x-ray diffraction | A, B | — | — |
| 5E18 | T. thermophilus transcription initiation complex having a yyy discriminator sequence and a… | x-ray diffraction | A, B | — | — |
| 5TMC | Re-refinement of thermus thermopiles DNA-directed RNA polymerase structure | x-ray diffraction | A, B | PO4 | — |
| 5TMF | Re-refinement of thermus thermophilus RNA polymerase | x-ray diffraction | A, B | PO4, MG | — |
| 5X21 | Crystal structure of thermus thermophilus transcription initiation complex with gpa and… | x-ray diffraction | A, B | MG | — |
| 5X22 | Crystal structure of thermus thermophilus transcription initiation complex with gpa and cmpcpp | x-ray diffraction | A, B, K, L | MG | — |
| 6OVY | X-ray crystal structure of a bacterial reiterative transcription complex of pyrg promoter variant… | x-ray diffraction | A, B | — | — |
| 6OW3 | X-ray crystal structure of a bacterial reiterative transcription complex of pyrg promoter variant… | x-ray diffraction | A, B | MG | — |
| 6OY5 | X-ray crystal structure of a bacterial reiterative transcription complex of pyrg promoter at 3 min | x-ray diffraction | A, B | MG | — |
| 6OY6 | X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter at 5 min | x-ray diffraction | A, B | MG | 6 (best 0.86) |
| 6OY6 | X-ray crystal structure of a bacterial reiterative transcription complex of pyrg promoter at 5 min | x-ray diffraction | A, B | MG | — |
| 6OY7 | X-ray crystal structure of a bacterial reiterative transcription complex of pyrg promoter at 7 min | x-ray diffraction | A, B | MG | — |
| 6P70 | X-ray crystal structure of bacterial RNA polymerase and pyrbi promoter complex | x-ray diffraction | A, B | MG | — |
| 6P71 | X-ray crystal structure of a bacterial reiterative transcription complex of pyrbi promoter | x-ray diffraction | A, B | — | — |
| 6WOX | Thermus thermophilus RNA polymerase initially transcribing complex with 2'DCTP | x-ray diffraction | A, B | — | — |
| 6WOY | Thermus thermophilus RNA polymerase initially transcribing complex with 3'DCTP | x-ray diffraction | A, B | — | — |
| Q9Z9H6 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (Q9Z9H6) | predicted | A | — | 3 (best 0.47) |
Ligands
Experiment against prediction
- 6P71 chain A against the predicted model Q9Z9H6: TM-score 0.97, RMSD 1.08 Å
- 6P70 chain A against the predicted model Q9Z9H6: TM-score 0.97, RMSD 1.08 Å
- 6OW3 chain A against the predicted model Q9Z9H6: TM-score 0.97, RMSD 1.09 Å
- 6OY7 chain A against the predicted model Q9Z9H6: TM-score 0.97, RMSD 1.10 Å
- 5X21 chain A against the predicted model Q9Z9H6: TM-score 0.97, RMSD 1.09 Å
- 6OVY chain A against the predicted model Q9Z9H6: TM-score 0.97, RMSD 1.10 Å
- 4Q5S chain A against the predicted model Q9Z9H6: TM-score 0.97, RMSD 1.09 Å
- 4Q5S chain A against the predicted model Q9Z9H6: TM-score 0.97, RMSD 1.09 Å
- 6OY6 chain A against the predicted model Q9Z9H6: TM-score 0.97, RMSD 1.13 Å
- 6OY6 chain A against the predicted model Q9Z9H6: TM-score 0.97, RMSD 1.13 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.