UniProt Q8RQE8
DNA-directed RNA polymerase subunit beta' (Q8RQE8)
DNA-directed RNA polymerase subunit beta' (UniProt Q8RQE8), EC 2.7.7.6: 153 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 619 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8RQE8
- Protein
- DNA-directed RNA polymerase subunit beta'
- EC
- 2.7.7.6
- Experimental structures
- 153
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 619 · 44 records with a druggable one
Structures
154 records of Q8RQE8 in the MolNFT archive: 153 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1SMY | Structural basis for transcription regulation by alarmone ppGpp | x-ray diffraction | D, N | MG, ZN, G4P | 13 (best 0.87) |
| 1SMY | Structural basis for transcription regulation by alarmone ppgpp | x-ray diffraction | D, N | — | — |
| 1ZYR | Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic… | x-ray diffraction | D, N | — | — |
| 1ZYR | Structure of thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic… | x-ray diffraction | D, N | — | — |
| 2A68 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | D, N | — | — |
| 2A68 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | D, N | — | — |
| 2A69 | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | D, N | — | — |
| 2A69 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | D, N | — | — |
| 2A6E | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme | x-ray diffraction | D, N | — | — |
| 2A6E | Crystal structure of the T. thermophilus RNA polymerase holoenzyme | x-ray diffraction | D, N | — | — |
| 2A6H | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | D, N | — | — |
| 2A6H | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | D, N | — | — |
| 2BE5 | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor… | x-ray diffraction | D, N | — | — |
| 2BE5 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with inhibitor… | x-ray diffraction | D, N | — | — |
| 2CW0 | Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution | x-ray diffraction | D, N | — | — |
| 2CW0 | Crystal structure of thermus thermophilus RNA polymerase holoenzyme at 3.3 ångströms resolution | x-ray diffraction | D, N | — | — |
| 2O5I | Crystal structure of the T. thermophilus RNA polymerase elongation complex | x-ray diffraction | D, N | — | — |
| 2O5I | Crystal structure of the T. thermophilus RNA polymerase elongation complex | x-ray diffraction | D, N | — | — |
| 2O5J | Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the NTP substrate… | x-ray diffraction | D, N | — | — |
| 2O5J | Crystal structure of the T. thermophilus rnap polymerase elongation complex with the ntp substrate… | x-ray diffraction | D, N | — | — |
| 2PPB | Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the ntp substrate… | x-ray diffraction | D, N | — | — |
| 2PPB | Crystal structure of the T. thermophilus rnap polymerase elongation complex with the ntp substrate… | x-ray diffraction | D, N | — | — |
| 3AOH | RNA polymerase-Gfh1 complex (Crystal type 1) | x-ray diffraction | D, I, N | — | — |
| 3AOH | RNA polymerase-GFH1 complex (crystal type 1) | x-ray diffraction | D, I, N | — | — |
| 3AOI | RNA polymerase-Gfh1 complex (Crystal type 2) | x-ray diffraction | D, I, N | — | — |
| 3AOI | RNA polymerase-GFH1 complex (crystal type 2) | x-ray diffraction | D, I, N | — | — |
| 3DXJ | Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic… | x-ray diffraction | D, N | — | — |
| 3DXJ | Crystal structure of thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic… | x-ray diffraction | D, N | — | — |
| 3EQL | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | D, N | — | — |
| 3EQL | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | D, N | — | — |
| 3WOD | RNA polymerase-gp39 complex | x-ray diffraction | D | — | — |
| 3WOD | RNA polymerase-GP39 complex | x-ray diffraction | D | — | — |
| 4G7H | Crystal structure of Thermus thermophilus transcription initiation complex | x-ray diffraction | D, N | — | — |
| 4G7H | Crystal structure of thermus thermophilus transcription initiation complex | x-ray diffraction | D, N | — | — |
| 4G7O | Crystal structure of Thermus thermophilus transcription initiation complex containing 2 nt of RNA | x-ray diffraction | D, N | — | — |
| 4G7O | Crystal structure of thermus thermophilus transcription initiation complex containing 2 nt of RNA | x-ray diffraction | D, N | — | — |
| 4G7Z | Crystal structure of Thermus thermophilus transcription initiation complex containing 5-BrU at… | x-ray diffraction | D, N | — | — |
| 4G7Z | Crystal structure of thermus thermophilus transcription initiation complex containing 5-bru at… | x-ray diffraction | D, N | — | — |
| 4GZY | Crystal structures of bacterial RNA Polymerase paused elongation complexes | x-ray diffraction | D | — | — |
| 4GZY | Crystal structures of bacterial RNA polymerase paused elongation complexes | x-ray diffraction | D | — | — |
| 4GZZ | Crystal structures of bacterial RNA Polymerase paused elongation complexes | x-ray diffraction | D | — | — |
| 4GZZ | Crystal structures of bacterial RNA polymerase paused elongation complexes | x-ray diffraction | D | — | — |
| 4MQ9 | Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 | x-ray diffraction | D | — | — |
| 4MQ9 | Crystal structure of thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 | x-ray diffraction | D | — | — |
| 4OIN | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 | x-ray diffraction | D | — | — |
| 4OIN | Crystal structure of thermus thermophilus transcription initiation complex soaked with GE23077 | x-ray diffraction | D | — | — |
| 4OIO | Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription… | x-ray diffraction | D | — | — |
| 4OIO | Crystal structure of thermus thermophilus pre-insertion substrate complex for de novo transcription… | x-ray diffraction | D | — | — |
| 4OIP | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077… | x-ray diffraction | D | — | — |
| 4OIP | Crystal structure of thermus thermophilus transcription initiation complex soaked with GE23077… | x-ray diffraction | D | — | — |
| 4OIQ | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and… | x-ray diffraction | D | — | — |
| 4OIQ | Crystal structure of thermus thermophilus transcription initiation complex soaked with GE23077 and… | x-ray diffraction | D | — | — |
| 4OIR | Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked… | x-ray diffraction | D | — | — |
| 4OIR | Crystal structure of thermus thermophilus RNA polymerase transcription initiation complex soaked… | x-ray diffraction | D | — | — |
| 4Q4Z | Thermus thermophilus RNA polymerase de novo transcription initiation complex | x-ray diffraction | D | — | — |
| 4Q4Z | Thermus thermophilus RNA polymerase de novo transcription initiation complex | x-ray diffraction | D | — | — |
| 4Q5S | Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA | x-ray diffraction | D | — | — |
| 4Q5S | Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA | x-ray diffraction | D | — | — |
| 4WQS | Thermus thermophilus RNA polymerase backtracked complex | x-ray diffraction | D, N | — | — |
| 4WQT | Thermus thermophilus RNA polymerase complexed with an RNA cleavage stimulating factor (a GREA/GFH1… | x-ray diffraction | D, I, N | — | — |
94 records more on the page itself.
Ligands
- ZN · Zinc ion · in 88 records
- MG · Magnesium ion · in 86 records
- POP · Pyrophosphate 2- · in 10 records
- 2TM · 5'-O-[(S)-hydroxy{[(s)-hydroxy(phosphonooxy) phosphoryl]methyl}phosphoryl]cytidine · in 6 records
- GTP · Guanosine-5'-triphosphate · in 4 records
- G4P · Guanosine-5',3'-tetraphosphate · in 3 records
- CH1 · 3'-deoxy-cytidine-5'-triphosphate · in 2 records
- DCP · 2'-deoxycytidine-5'-triphosphate · in 2 records
- NA · Sodium ion · in 2 records
- NE6 · Methyl [(1E,5R)-5-{(3S)-3-[(2E,4E)-2,5-dimethylocta-2, 4-dienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate · in 2 records
- PO4 · Phosphate ion · in 2 records
- PUM · (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2, 3,4-tetrahydropyrimidin-5-yl)-D-ribitol · in 2 records
- UTP · Uridine 5'-triphosphate · in 2 records
- C5P · Cytidine-5'-monophosphate · in 1 record
- COD · Dephospho coenzyme A · in 1 record
- DPO · Diphosphate · in 1 record
Experiment against prediction
- 5I2D chain D against the predicted model Q8RQE8: TM-score 0.99, RMSD 1.23 Å
- 7RDQ chain D against the predicted model Q8RQE8: TM-score 0.99, RMSD 1.37 Å
- 8W8O chain D against the predicted model Q8RQE8: TM-score 0.98, RMSD 1.69 Å
- 6P70 chain D against the predicted model Q8RQE8: TM-score 0.98, RMSD 1.73 Å
- 6OY5 chain D against the predicted model Q8RQE8: TM-score 0.98, RMSD 1.73 Å
- 6OY6 chain D against the predicted model Q8RQE8: TM-score 0.98, RMSD 1.74 Å
- 6KQN chain D against the predicted model Q8RQE8: TM-score 0.98, RMSD 1.77 Å
- 6KQL chain D against the predicted model Q8RQE8: TM-score 0.98, RMSD 1.76 Å
- 6P71 chain D against the predicted model Q8RQE8: TM-score 0.98, RMSD 1.78 Å
- 6KQH chain D against the predicted model Q8RQE8: TM-score 0.98, RMSD 1.79 Å
Elsewhere
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