Research workbench
The crystal structure of the human sex hormone-binding globulin (tetragonal crystal form)
Analyse The crystal structure of the human sex hormone-binding globulin (tetragonal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1KDM
- Type
- protein
- Length
- 177 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sex hormone-binding globulin
- UniProt
- P04278
- Ligands
- DHT, CA
- Pockets
- 2 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sex hormone-binding globulin | protein | 177 | 5% helix, 47% strand | P04278 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.84 | 0.98 | 26 | DHT |
| 2 | 74 | 0.32 | 0.74 | 23 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1KDM · The crystal structure of the human sex hormone-binding globulin (tetragonal crystal form) · the same entry in another collection · chain A against A, TM-score 1.00
- P04278 · AlphaFold monomer V2.0 prediction for sex hormone-binding globulin (P04278) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04278
- Elsewhere: RCSB PDB 1KDM · PDBe 1KDM · UniProt P04278
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