MolNFT v1 · #428095 · protein
AlphaFold monomer V2.0 prediction for sex hormone-binding globulin (P04278)
P04278: “AlphaFold monomer V2.0 prediction for sex hormone-binding globulin (P04278)”. 3 pockets (best druggability 0.81). MolNFT v1 #428095 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P04278
- Type
- protein
- Length
- 402 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xd10960F956646DE8b64d3598984c91C2d5Af3D7b
- Molecule
- Sex hormone-binding globulin
- UniProt
- P04278
- Pockets
- 3 · best druggability 0.81
Structure
1 distinct chain · 9% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sex hormone-binding globulin | protein | 402 | 9% helix, 44% strand | P04278 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.81 | 0.98 | 24 | empty |
| 2 | 83 | 0.38 | 0.77 | 23 | empty |
| 3 | 69 | 0.33 | 0.76 | 24 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1KDM · The crystal structure of the human sex hormone-binding globulin (tetragonal crystal form) · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1KDM · The crystal structure of the human sex hormone-binding globulin (tetragonal crystal form) · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1KDK · The structure of the N-terminal lg domain of shbg in crystals soaked with edta · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1KDK · The structure of the N-terminal lg domain of shbg in crystals soaked with edta · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1LHO · Crystal structure of the N-terminal lg-domain of shbg in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1LHO · Crystal structure of the N-terminal lg-domain of shbg in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1LHN · Crystal structure of the N-terminal lg-domain of shbg in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1LHN · Crystal structure of the N-terminal lg-domain of shbg in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1LHU · Crystal structure of the N-terminal lg-domain of shbg in complex with estradiol · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 1LHU · Crystal structure of the N-terminal lg-domain of shbg in complex with estradiol · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 6PYF · Sex hormone-binding globulin mutant E176K in complex with estradiol · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 6PYF · Sex Hormone-binding globulin mutant E176K in complex with Estradiol · an experimental structure of the same protein · chain A against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04278
- Elsewhere: UniProt P04278 · AlphaFold DB P04278
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