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Ligand · DHT

DHT · 5-alpha-dihydrotestosterone

DHT, 5-alpha-dihydrotestosterone (C19 H30 O2, 290.4 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (8 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with…

Component
DHT
Formula
C19 H30 O2
Class
ligand
Structures
8
PDB entries
8

Binding sites

DHT in 8 structures; the first of them:

  • 5JJM · Crystal Structure of Homodimeric Androgen Receptor Ligand-Binding Domain bound to DHT and… · DHT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, TRP741, MET742 and 13 more
  • 7ZTV · Crystal structure of mutant AR-LBD (F755L) bound to dihydrotestosterone · DHT A1001 · binds LEU702, LEU705, ASN706, LEU708, GLY709, GLN712, TRP742, MET743 and 13 more
  • 7ZTX · Crystal structure of mutant AR-LBD (F755V) bound to dihydrotestosterone · DHT A1001 · binds LEU702, LEU705, ASN706, LEU708, GLY709, GLN712, TRP742, MET743 and 13 more
  • 7ZU1 · Crystal structure of mutant AR-LBD (V758A) bound to dihydrotestosterone · DHT A1001 · binds LEU702, LEU705, ASN706, LEU708, GLY709, GLN712, TRP742, MET743 and 13 more
  • 8FGY · Crystal structure of mutant Androgen Receptor ligand binding domain… · DHT A1001 · binds HIS702, LEU705, ASN706, LEU708, GLY709, GLN712, TRP742, MET743 and 11 more
  • 8FGZ · Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y/F877L… · DHT A1001 · binds LEU705, ASN706, LEU708, GLN712, MET743, MET746, MET750, ARG753 and 6 more
  • 8FH1 · Crystal structure of mutant Androgen Receptor ligand binding domain F877L/T878A with DHT · DHT A1001 · binds LEU702, LEU705, ASN706, LEU708, GLY709, GLN712, TRP742, MET743 and 12 more
  • 7RAE · ANCAR1 - progesterone - TIF2 · DHT A1001 · binds LEU704, ASN705, GLY708, GLN711, MET742, MET745, MET749, ARG752 and 5 more

Residues it binds most

MET 11, LEU 11, PHE 11, ARG 11, ASN 11, GLN 11, GLY 10, THR 9, TRP 9, VAL 9 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • GOL · Glycerol
  • EDO · 1,2-ethanediol
  • IMD · Imidazole
  • LI · Lithium ion
  • ZN · Zinc ion
  • CL · Chloride ion
  • ACT · Acetate ion
  • DTT · 2,3-dihydroxy-1,4-dithiobutane
  • PGE · Triethylene glycol

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