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Ligand · 4HY

4HY · [4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-acetic acid

4HY, [4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-acetic acid (C14 H9 I3 O4, 621.9 g/mol), in the MolNFT structures on GenesisL1: bound in 26 records (13 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
4HY
Formula
C14 H9 I3 O4
Class
ligand
Structures
26
PDB entries
13

Binding sites

4HY in 26 structures; the first of them:

  • 1NQ0 · TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release… · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, SER314 and 13 more
  • 1NQ1 · TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release… · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, ARG316 and 12 more
  • 1NQ2 · Two RTH Mutants with Impaired Hormone Binding · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, ARG282, MET310, MET313 and 14 more
  • 1NUO · Two RTH Mutants with Impaired Hormone Binding · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, HIS316 and 10 more
  • 2PIN · Thyroid receptor beta in complex with inhibitor · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, ARG316 and 12 more
  • 2PIT · Androgen receptor LBD with small molecule · 4HY A933 · binds PHE673, PRO723, GLY724, ASN727, GLU829, LEU830, ASN833, TYR834 and 2 more
  • 2PIU · Androgen receptor LBD with small molecule · 4HY A932 · binds LEU712, VAL713, VAL716, LYS717, LYS720, MET734, ILE737, GLN738 and 2 more
  • 2PKL · Androgen receptor LBD with small molecule · 4HY A932 · binds PHE673, PRO723, GLY724, ASN727, PHE826, GLU829, LEU830, ASN833 and 3 more
  • 2QPY · AR LBD with small molecule · 4HY A1 · binds PHE673, PRO723, GLY724, ASN727, PHE826, GLU829, LEU830, ASN833 and 3 more
  • 3D57 · TR Variant D355R · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, ARG316 and 12 more
  • 3JZB · Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC · 4HY A1 · binds PHE215, PHE218, ILE221, ILE222, ALA225, ARG228, MET256, MET259 and 15 more
  • 3JZC · Crystal Structure of TR-beta bound to the selective thyromimetic TRIAC · 4HY A1 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, SER314 and 13 more
  • 4YX9 · Crystal structure of the CFTR inhibitory factor Cif bound to tiratricol · 4HY A401 · binds GLU153, PRO155, ARG163, PHE164, PRO165, SER173, LEU174, VAL175 and 7 more
  • 1NQ0 · Tr receptor mutations conferring hormone resistance and reduced corepressor release… · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, SER314 and 13 more
  • 1NQ1 · Tr receptor mutations conferring hormone resistance and reduced corepressor release… · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, ARG316 and 12 more
  • 1NQ2 · Two rth mutants with impaired hormone binding · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, ARG282, MET310, MET313 and 14 more
  • 1NUO · Two rth mutants with impaired hormone binding · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, HIS316 and 10 more
  • 2PIN · Thyroid receptor beta in complex with inhibitor · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, ARG316 and 12 more
  • 2PIT · Androgen receptor lbd with small molecule · 4HY A933 · binds PHE673, PRO723, GLY724, ASN727, GLU829, LEU830, ASN833, TYR834 and 2 more
  • 2PIU · Androgen receptor lbd with small molecule · 4HY A932 · binds LEU712, VAL713, VAL716, LYS717, LYS720, MET734, ILE737, GLN738 and 2 more
  • 2PKL · Androgen receptor lbd with small molecule · 4HY A932 · binds PHE673, PRO723, GLY724, ASN727, PHE826, GLU829, LEU830, ASN833 and 3 more
  • 2QPY · Ar lbd with small molecule · 4HY A1 · binds PHE673, PRO723, GLY724, ASN727, PHE826, GLU829, LEU830, ASN833 and 3 more
  • 3D57 · Tr variant D355R · 4HY A500 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, ARG316 and 12 more
  • 3JZB · Crystal structure of tr-alfa bound to the selective thyromimetic triac · 4HY A1 · binds PHE215, PHE218, ILE221, ILE222, ALA225, ARG228, MET256, MET259 and 15 more
  • 3JZC · Crystal structure of tr-beta bound to the selective thyromimetic triac · 4HY A1 · binds PHE269, PHE272, ILE275, ILE276, ALA279, MET310, MET313, SER314 and 13 more
  • 4YX9 · Crystal structure of the cftr inhibitory factor cif bound to tiratricol · 4HY A401 · binds GLU153, PRO155, ARG163, PHE164, PRO165, SER173, LEU174, VAL175 and 7 more

Residues it binds most

PHE 36, LEU 38, MET 30, ILE 22, ARG 30, GLY 34, HIS 28, ALA 20, ASN 26, PRO 16 (residue and the binding sites it lines).

Found with

  • DHT · 5-alpha-dihydrotestosterone
  • ARS · Arsenic
  • SO4 · Sulfate ion
  • LEG · 1-(4-hexylphenyl)prop-2-en-1-one
  • NA · Sodium ion

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