MolNFT v1 · #16141 · protein
Tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the nterminal lbd
1NQ0 · Thyroid hormone receptor beta-1: “Tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased…”. X-ray diffraction, 2 ligands (4HY, ARS), 3 pockets (best druggability 0.82). MolNFT v1 #16141…
- PDB
- 1NQ0
- Type
- protein
- Length
- 253 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thyroid hormone receptor beta-1
- UniProt
- P10828
- Ligands
- 4HY, ARS
- Pockets
- 3 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 67% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thyroid hormone receptor beta-1 | protein | 253 | 67% helix, 4% strand | P10828 |
Ligands and binding sites
- 4HY · [4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-acetic acid · ligand · chains A
- ARS · Arsenic · metal · 6 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 199 | 0.82 | 0.96 | 31 | 4HY |
| 2 | 125 | 0.45 | 0.77 | 20 | empty |
| 3 | 109 | 0.37 | 0.74 | 16 | empty |
Compared structures
- 1NQ0 · TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release… · the same entry in another collection · chain A against A, TM-score 1.00
- P10828 · AlphaFold monomer V2.0 prediction for thyroid hormone receptor beta (P10828) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10828
- Elsewhere: RCSB PDB 1NQ0 · PDBe 1NQ0 · UniProt P10828
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