UniProt P10828
Isoform Beta-2 of Thyroid hormone receptor beta (P10828)
Isoform Beta-2 of Thyroid hormone receptor beta (UniProt P10828): 62 experimental structures on GenesisL1, 9 ligands bound, 27 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P10828
- Protein
- Isoform Beta-2 of Thyroid hormone receptor beta
- Experimental structures
- 62
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 27 · 8 records with a druggable one
Structures
62 records of P10828 in the MolNFT archive: 62 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BSX | Structure and specificity of nuclear receptor-coactivator interactions | x-ray diffraction | A, B | — | — |
| 1BSX | Structure and specificity of nuclear receptor-coactivator interactions | x-ray diffraction | A, B | — | — |
| 1N46 | Crystal structure of human tr beta ligand-binding domain complexed with a potent subtype-selective… | x-ray diffraction | A, B | — | — |
| 1N46 | Crystal structure of human tr beta ligand-binding domain complexed with a potent subtype-selective… | x-ray diffraction | A, B | — | — |
| 1NAX | Thyroid receptor beta1 in complex with a beta-selective ligand | x-ray diffraction | A | — | — |
| 1NAX | Thyroid receptor BETA1 in complex with a beta-selective ligand | x-ray diffraction | A | — | — |
| 1NQ0 | TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit… | x-ray diffraction | A | — | — |
| 1NQ0 | Tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit… | x-ray diffraction | A | — | — |
| 1NQ1 | TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit… | x-ray diffraction | A | — | — |
| 1NQ1 | Tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit… | x-ray diffraction | A | — | — |
| 1NQ2 | Two RTH Mutants with Impaired Hormone Binding | x-ray diffraction | A | — | — |
| 1NQ2 | Two rth mutants with impaired hormone binding | x-ray diffraction | A | — | — |
| 1NUO | Two RTH Mutants with Impaired Hormone Binding | x-ray diffraction | A | — | — |
| 1NUO | Two rth mutants with impaired hormone binding | x-ray diffraction | A | — | — |
| 1Q4X | Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-24 | x-ray diffraction | A | — | — |
| 1Q4X | Crystal structure of human thyroid hormone receptor beta lbd in complex with specific agonist gc-24 | x-ray diffraction | A | — | — |
| 1R6G | Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta… | x-ray diffraction | A | — | — |
| 1R6G | Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta… | x-ray diffraction | A | — | — |
| 1XZX | Thyroxine-Thyroid Hormone Receptor Interactions | x-ray diffraction | X | — | — |
| 1XZX | Thyroxine-thyroid hormone receptor interactions | x-ray diffraction | X | — | — |
| 1Y0X | Thyroxine-Thyroid Hormone Receptor Interactions | x-ray diffraction | X | — | — |
| 1Y0X | Thyroxine-thyroid hormone receptor interactions | x-ray diffraction | X | — | — |
| 2J4A | Human Thyroid hormone receptor beta ligand binding domain in complex with KB131084 | x-ray diffraction | A | — | — |
| 2J4A | Human thyroid hormone receptor beta ligand binding domain in complex with KB131084 | x-ray diffraction | A | — | — |
| 2NLL | Retinoid X receptor-thyroid hormone receptor DNA-binding domain heterodimer bound to thyroid… | x-ray diffraction | B | — | — |
| 2NLL | Retinoid X receptor-thyroid hormone receptor DNA-binding domain heterodimer bound to thyroid… | x-ray diffraction | B | — | — |
| 2PIN | Thyroid receptor beta in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 2PIN | Thyroid receptor beta in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 3D57 | TR Variant D355R | x-ray diffraction | A, B | — | — |
| 3D57 | Tr variant D355R | x-ray diffraction | A, B | — | — |
| 3GWS | Crystal Structure of T3-Bound Thyroid Hormone Receptor | x-ray diffraction | X | — | — |
| 3GWS | Crystal structure of T3-bound thyroid hormone receptor | x-ray diffraction | X | — | — |
| 3IMY | Structure of TR-beta bound to selective thyromimetic GC-1 | x-ray diffraction | A | — | — |
| 3IMY | Structure of tr-beta bound to selective thyromimetic gc-1 | x-ray diffraction | A | — | — |
| 3JZC | Crystal Structure of TR-beta bound to the selective thyromimetic TRIAC | x-ray diffraction | A | — | — |
| 3JZC | Crystal structure of tr-beta bound to the selective thyromimetic triac | x-ray diffraction | A | — | — |
| 4ZO1 | Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha | x-ray diffraction | X | T3 | 7 (best 0.83) |
| 4ZO1 | Crystal structure of the T3-bound tr-beta ligand-binding domain in complex with rxr-alpha | x-ray diffraction | X | — | — |
| 6KKB | A novel agonist of THRb | x-ray diffraction | X | 8HO | — |
| 6KKB | A novel agonist of thrb | x-ray diffraction | X | 8HO | — |
| 6KKE | THRb mutation with a novel agonist | x-ray diffraction | A | 8HO | — |
| 6KKE | Thrb mutation with a novel agonist | x-ray diffraction | A | 8HO | — |
| 6KNU | THRb mutation with a novel agonist | x-ray diffraction | A | 8HO | — |
| 6KNU | Thrb mutation with a novel agonist | x-ray diffraction | A | 8HO | — |
| 6KNV | THRb mutation with a novel agonist | x-ray diffraction | A | 8HO | — |
| 6KNV | Thrb mutation with a novel agonist | x-ray diffraction | A | 8HO | — |
| 6KNW | Thrb mutation with a novel agonist | x-ray diffraction | A | 8HO | — |
| 7WLX | A novel chemical derivative(53) of THRB agonist | x-ray diffraction | A | 9GC | 3 (best 0.81) |
| 7WLX | A novel chemical DERIVATIVE(53) of thrb agonist | x-ray diffraction | A | 9GC | — |
| 7WMG | A novel chemical derivative(52) of THRB agonist | x-ray diffraction | A | 9IF | 2 (best 0.81) |
| 7WMG | A novel chemical DERIVATIVE(52) of thrb agonist | x-ray diffraction | A | 9IF | — |
| 7WMH | A novel chemical derivative(56) of THRB agonist | x-ray diffraction | A | 9II | 3 (best 0.84) |
| 7WMH | A novel chemical DERIVATIVE(56) of thrb agonist | x-ray diffraction | A | 9II | — |
| 7WMJ | A novel chemical derivative(71) of THRB agonist | x-ray diffraction | A | 9IL | 3 (best 0.83) |
| 7WMJ | A novel chemical DERIVATIVE(71) of thrb agonist | x-ray diffraction | A | 9IL | — |
| 7WML | A novel chemical derivative(85) of THRB agonist | x-ray diffraction | A | 9IQ | 3 (best 0.81) |
| 7WML | A novel chemical DERIVATIVE(85) of thrb agonist | x-ray diffraction | A | 9IQ | — |
| 7WMN | A novel chemical derivative(89) of THRB agonist | x-ray diffraction | A | 9IT | 3 (best 0.84) |
| 7WMN | A novel chemical DERIVATIVE(89) of thrb agonist | x-ray diffraction | A | 9IT | — |
| 7WMO | A novel chemical derivative(92) of THRB agonist | x-ray diffraction | A | 9IW | 3 (best 0.81) |
2 records more on the page itself.
Ligands
- 8HO · 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl) carbonylamino]ethanoic acid · in 9 records
- 9GC · 2-[[1-methoxy-4-oxidanyl-7-[4-(phenylmethyl) phenoxy]isoquinolin-3-yl]carbonylamino]ethanoic acid · in 2 records
- 9IF · 2-[[1-methoxy-4-oxidanyl-7-(4-phenoxyphenoxy) isoquinolin-3-yl]carbonylamino]ethanoic acid · in 2 records
- 9II · 2-[[1-methoxy-4-oxidanyl-7-(4-phenylphenoxy) isoquinolin-3-yl]carbonylamino]ethanoic acid · in 2 records
- 9IL · 2-[[7-[2,6-dimethyl-4-(phenylcarbonyl)phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid · in 2 records
- 9IQ · 2-[[7-[4-(3,5-dimethylphenyl)carbonyl-2,6-dimethyl-phenoxy]-1-ethoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid · in 2 records
- 9IT · 2-[[7-[2,6-dimethyl-4-(3-methylphenyl)carbonyl-phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid · in 2 records
- 9IW · 2-[[1-ethoxy-7-[4-(3-fluoranyl-5-methoxy-phenyl) carbonyl-2,6-dimethyl-phenoxy]-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid · in 2 records
- T3 · 3,5,3'triiodothyronine · in 1 record
Elsewhere
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