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Ligand · G24

G24 · [4-(3-benzyl-4-hydroxybenzyl)-3,5-dimethylphenoxy]acetic acid

G24, [4-(3-benzyl-4-hydroxybenzyl)-3,5-dimethylphenoxy]acetic acid (C24 H24 O4, 376.4 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
G24
Formula
C24 H24 O4
Class
ligand
Structures
6
PDB entries
3

Binding sites

G24 in 6 structures; the first of them:

  • 1Q4X · Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific… · G24 A462 · binds ALA234, PHE269, PHE272, THR273, ILE275, ILE276, ALA279, ARG282 and 18 more
  • 3NEO · Wild type human transthyretin (TTR) complexed with GC-24 (TTRwt:GC-24) · G24 A1 · binds MET13, LYS15, LEU17, GLU54, THR106, ALA108, ALA109, LEU110 and 1 more
  • 3NEX · V30M mutant human transthyretin (TTR) complexed with GC-24 (V30M:GC-24) · G24 A126 · binds MET13, LYS15, LEU17, GLU54, THR106, ALA108, ALA109, LEU110 and 1 more
  • 1Q4X · Crystal structure of human thyroid hormone receptor beta lbd in complex with specific… · G24 A462 · binds ALA234, PHE269, PHE272, THR273, ILE275, ILE276, ALA279, ARG282 and 18 more
  • 3NEO · Wild type human transthyretin (ttr) complexed with gc-24 (TTRWT:GC-24) · G24 A1 · binds MET13, LYS15, LEU17, GLU54, THR106, ALA108, ALA109, LEU110 and 1 more
  • 3NEX · V30M mutant human transthyretin (ttr) complexed with gc-24 (V30M:GC- 24) · G24 A126 · binds MET13, LYS15, LEU17, GLU54, THR106, ALA108, ALA109, LEU110 and 1 more

Residues it binds most

LEU 12, ALA 10, THR 10, SER 8, MET 8, GLU 8, LYS 8, PHE 2, ARG 2, GLY 2 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol

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