GL1X · GenesisL1 explorer

Ligand · IH5

IH5 · {3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenoxy]phenyl}acetic acid

IH5, {3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenoxy]phenyl}acetic acid (C17 H16 Cl2 O4, 355.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
IH5
Formula
C17 H16 Cl2 O4
Class
ligand
Structures
4
PDB entries
2

Binding sites

IH5 in 4 structures; the first of them:

  • 1NAV · Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1 · IH5 A600 · binds PHE215, PHE218, THR219, ILE221, ILE222, ALA225, ARG228, MET256 and 15 more
  • 1NAX · Thyroid receptor beta1 in complex with a beta-selective ligand · IH5 A501 · binds PHE269, PHE272, THR273, ILE275, ILE276, ALA279, ARG282, MET310 and 16 more
  • 1NAV · Thyroid receptor alpha in complex with an agonist selective for thyroid receptor BETA1 · IH5 A600 · binds PHE215, PHE218, THR219, ILE221, ILE222, ALA225, ARG228, MET256 and 15 more
  • 1NAX · Thyroid receptor BETA1 in complex with a beta-selective ligand · IH5 A501 · binds PHE269, PHE272, THR273, ILE275, ILE276, ALA279, ARG282, MET310 and 16 more

Residues it binds most

GLY 4, ILE 4, LEU 4, MET 4, PHE 4, ALA 4, THR 4, ARG 4, SER 4, HIS 4 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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