Research workbench
PI4K iialpha bound to calcium
Analyse PI4K iialpha bound to calcium in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5I0N
- Type
- protein
- Length
- 489 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 4-kinase type 2-ALPHA,LYSOZYME, phosphatidylinositol 4-kinase type…
- EC
- 2.7.1.67, 3.2.1.17
- UniProt
- Q9BTU6, D9IEF7
- Ligands
- ATP, CA
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 4-kinase type 2-ALPHA,LYSOZYME, phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67, 3.2.1.17) | protein | 489 | 50% helix, 11% strand | Q9BTU6, D9IEF7 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 373 | 0.66 | 0.80 | 57 | ATP, CA |
| 2 | 248 | 0.54 | 0.77 | 29 | empty |
| 3 | 98 | 0.48 | 0.81 | 16 | ATP |
| 4 | 140 | 0.41 | 0.74 | 24 | empty |
| 5 | 120 | 0.36 | 0.73 | 20 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BTU6
- Every structure of UniProt D9IEF7
- Elsewhere: RCSB PDB 5I0N · PDBe 5I0N · UniProt Q9BTU6 · UniProt D9IEF7
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