Research workbench

Structure of a fragment of human phospholipase C-BETA3 DELTA472-559, in complex with galphaq

Analyse Structure of a fragment of human phospholipase C-BETA3 DELTA472-559, in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4QJ3
Type: protein
Length: 1,072 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanine nucleotide-binding protein G(Q) subunit alpha; 1-phosphatidylinositol…
EC: 3.1.4.11
UniProt: P21279, Q01970
Ligands: GDP, ALF, MG, CA
Pockets: 14 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Guanine nucleotide-binding protein G(Q) subunit alpha	protein	316	49% helix, 13% strand	P21279
B	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11)	protein	756	32% helix, 22% strand	Q01970

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A
ALF · Tetrafluoroaluminate ion · ligand · chains A
MG · Magnesium ion · metal · chains A
CA · Calcium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	932	0.79	0.81	64	empty
2	466	0.77	0.85	78	empty
3	244	0.71	0.86	28	empty
4	739	0.71	0.77	70	empty
5	279	0.69	0.84	41	GDP, ALF, MG

Interfaces

1 interface between chains.

A–B · 1713 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

4QJ3 · Structure of a fragment of human phospholipase C-beta3 delta472-559, in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Q01970 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate… · a predicted model of the same protein · chain B against A, TM-score 1.00
P21279 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(Q) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21279
Every structure of UniProt Q01970
Elsewhere: RCSB PDB 4QJ3 · PDBe 4QJ3 · UniProt P21279 · UniProt Q01970

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.