UniProt P21279
Guanine nucleotide-binding protein G(Q) subunit alpha (P21279)
Guanine nucleotide-binding protein G(Q) subunit alpha (UniProt P21279): 19 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P21279
- Protein
- Guanine nucleotide-binding protein G(Q) subunit alpha
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 3 · 1 record with a druggable one
Structures
20 records of P21279 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BCJ | Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma… | x-ray diffraction | Q | — | — |
| 2BCJ | Crystal structure of G protein-coupled receptor kinase 2 in complex with galpha-Q and gbetagamma… | x-ray diffraction | Q | — | — |
| 3AH8 | Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890 | x-ray diffraction | A | — | — |
| 3AH8 | Structure of heterotrimeric G protein galpha-Q beta gamma in complex with an inhibitor ym-254890 | x-ray diffraction | A | — | — |
| 4EKC | Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C) | x-ray diffraction | A, C | — | — |
| 4EKC | Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine galpha-Q(R183C) | x-ray diffraction | A, C | — | — |
| 4EKD | Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C) | x-ray diffraction | A | — | — |
| 4EKD | Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine galpha-Q(R183C) | x-ray diffraction | A | — | — |
| 4GNK | Crystal structure of Galphaq in complex with full-length human PLCbeta3 | x-ray diffraction | A, C | — | — |
| 4GNK | Crystal structure of galphaq in complex with full-length human PLCBETA3 | x-ray diffraction | A, C | — | — |
| 4QJ3 | Structure of a fragment of human phospholipase C-beta3 delta472-559, in complex with Galphaq | x-ray diffraction | A | — | — |
| 4QJ3 | Structure of a fragment of human phospholipase C-BETA3 DELTA472-559, in complex with galphaq | x-ray diffraction | A | — | — |
| 4QJ4 | Structure of a fragment of human phospholipase C-beta3 delta472-569, bound to IP3 and in complex… | x-ray diffraction | A | — | — |
| 4QJ4 | Structure of a fragment of human phospholipase C-BETA3 DELTA472-569, bound to IP3 and in complex… | x-ray diffraction | A | — | — |
| 4QJ5 | Structure of a fragment of human phospholipase C-beta3 delta472-581, bound to IP3 and in complex… | x-ray diffraction | A | — | — |
| 4QJ5 | Structure of a fragment of human phospholipase C-BETA3 DELTA472-581, bound to IP3 and in complex… | x-ray diffraction | A | — | — |
| 5DO9 | Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q | x-ray diffraction | A, C, E | GDP, ALF, MG | — |
| 5DO9 | Structure of regulator of G protein signaling 8 (RGS8) in complex with ALF4-activated galpha-Q | x-ray diffraction | A, C, E | — | — |
| 7SQ2 | Reprocessed and refined structure of phospholipase C-beta and gq signaling complex | x-ray diffraction | A | ALF, MG, GDP | — |
| P21279 | AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(Q) subunit alpha (P21279) | predicted | A | — | 3 (best 0.73) |
Ligands
Experiment against prediction
- 2BCJ chain Q against the predicted model P21279: TM-score 0.99, RMSD 0.73 Å
- 2BCJ chain Q against the predicted model P21279: TM-score 0.99, RMSD 0.73 Å
- 7SQ2 chain A against the predicted model P21279: TM-score 0.99, RMSD 0.86 Å
- 4QJ3 chain A against the predicted model P21279: TM-score 0.98, RMSD 0.89 Å
- 4QJ3 chain A against the predicted model P21279: TM-score 0.98, RMSD 0.89 Å
- 4EKD chain A against the predicted model P21279: TM-score 0.98, RMSD 0.85 Å
- 4EKD chain A against the predicted model P21279: TM-score 0.98, RMSD 0.85 Å
- 4EKC chain A against the predicted model P21279: TM-score 0.98, RMSD 0.88 Å
- 4EKC chain A against the predicted model P21279: TM-score 0.98, RMSD 0.88 Å
- 4GNK chain C against the predicted model P21279: TM-score 0.98, RMSD 1.01 Å
Elsewhere
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