UniProt Q01970
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (Q01970)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (UniProt Q01970), EC 3.1.4.11: 11 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 36 pockets. Binding sites, druggability and…
- UniProt
- Q01970
- Protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
- EC
- 3.1.4.11
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 36 · 3 records with a druggable one
Structures
12 records of Q01970 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4GNK | Crystal structure of Galphaq in complex with full-length human PLCbeta3 | x-ray diffraction | B, D, E | — | — |
| 4GNK | Crystal structure of galphaq in complex with full-length human PLCBETA3 | x-ray diffraction | B, D, E | — | — |
| 4QJ3 | Structure of a fragment of human phospholipase C-beta3 delta472-559, in complex with Galphaq | x-ray diffraction | B | — | — |
| 4QJ3 | Structure of a fragment of human phospholipase C-BETA3 DELTA472-559, in complex with galphaq | x-ray diffraction | B | — | — |
| 4QJ4 | Structure of a fragment of human phospholipase C-beta3 delta472-569, bound to IP3 and in complex… | x-ray diffraction | B | — | — |
| 4QJ4 | Structure of a fragment of human phospholipase C-BETA3 DELTA472-569, bound to IP3 and in complex… | x-ray diffraction | B | — | — |
| 4QJ5 | Structure of a fragment of human phospholipase C-beta3 delta472-581, bound to IP3 and in complex… | x-ray diffraction | B | — | — |
| 4QJ5 | Structure of a fragment of human phospholipase C-BETA3 DELTA472-581, bound to IP3 and in complex… | x-ray diffraction | B | — | — |
| 7SQ2 | Reprocessed and refined structure of phospholipase C-beta and gq signaling complex | x-ray diffraction | B | CA, MG | — |
| 8EMX | Phospholipase C beta 3 (PLCb3) in complex with Gbg on lipid nanodiscs | electron microscopy | A | CA | 14 (best 0.87) |
| 8UQO | PLCb3-Gbg-Gaq complex on membranes | electron microscopy | Q | CA | 12 (best 0.84) |
| Q01970 | AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase… | predicted | A | — | 10 (best 0.78) |
Ligands
Experiment against prediction
- 4QJ5 chain B against the predicted model Q01970: TM-score 1.00, RMSD 0.63 Å
- 4QJ5 chain B against the predicted model Q01970: TM-score 1.00, RMSD 0.63 Å
- 4QJ3 chain B against the predicted model Q01970: TM-score 1.00, RMSD 0.68 Å
- 4QJ3 chain B against the predicted model Q01970: TM-score 1.00, RMSD 0.68 Å
- 4QJ4 chain B against the predicted model Q01970: TM-score 1.00, RMSD 0.69 Å
- 4QJ4 chain B against the predicted model Q01970: TM-score 1.00, RMSD 0.69 Å
- 7SQ2 chain B against the predicted model Q01970: TM-score 0.99, RMSD 0.73 Å
- 8UQO chain Q against the predicted model Q01970: TM-score 0.99, RMSD 0.83 Å
- 4GNK chain B against the predicted model Q01970: TM-score 0.99, RMSD 0.87 Å
- 4GNK chain B against the predicted model Q01970: TM-score 0.99, RMSD 0.87 Å
Elsewhere
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