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AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor 18 (P33411)

Analyse AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor 18 (P33411) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
P33411
Type
protein
Length
251 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0x80D2ac0F5e3268bC5C1d28BBAA07E3169BB02b79
Molecule
Pre-mRNA-splicing factor 18
UniProt
P33411
Pockets
2 · best druggability 0.29

Structure

1 distinct chain · 62% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
APre-mRNA-splicing factor 18protein25162% helix, 0% strandP33411

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1640.290.7417empty
2610.280.7312empty

Compared structures

  • 1DVK · Crystal structure of the functional domain of the splicing factor PRP18 · an experimental structure of the same protein · chain A against B, TM-score 0.56
  • 1DVK · Crystal structure of the functional domain of the splicing factor PRP18 · an experimental structure of the same protein · chain A against B, TM-score 0.56
  • 5YLZ · Cryo-EM structure of the post-catalytic spliceosome from saccharomyces cerevisiae at 3.6… · an experimental structure of the same protein · chain A against U, TM-score 0.56
  • 5YLZ · Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6… · an experimental structure of the same protein · chain A against U, TM-score 0.56
  • 5WSG · Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom… · an experimental structure of the same protein · chain A against f, TM-score 0.56
  • 5WSG · Cryo-EM structure of the catalytic step II spliceosome (C* complex) at 4.0 ångström… · an experimental structure of the same protein · chain A against f, TM-score 0.56
  • 6EXN · Post-catalytic P complex spliceosome with 3' splice site docked · an experimental structure of the same protein · chain A against a, TM-score 0.55
  • 6EXN · Post-catalytic P complex spliceosome with 3' splice site docked · an experimental structure of the same protein · chain A against a, TM-score 0.55
  • 6BK8 · S. cerevisiae spliceosomal post-catalytic P complex · an experimental structure of the same protein · chain A against N, TM-score 0.54
  • 5MQ0 · Structure of a spliceosome remodeled for exon ligation · an experimental structure of the same protein · chain A against a, TM-score 0.53

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