Research workbench
AlphaFold monomer V2.0 prediction for kappa-type opioid receptor (P41145)
Analyse AlphaFold monomer V2.0 prediction for kappa-type opioid receptor (P41145) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P41145
- Type
- protein
- Length
- 380 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xe43F7D915A24c96B1cDb67a04105E34989DbaA45
- Molecule
- Kappa-type opioid receptor
- UniProt
- P41145
- Pockets
- 6 · best druggability 0.84
Structure
1 distinct chain · 71% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kappa-type opioid receptor | protein | 380 | 71% helix, 3% strand | P41145 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 263 | 0.84 | 0.95 | 41 | empty |
| 2 | 178 | 0.54 | 0.79 | 22 | empty |
| 3 | 206 | 0.50 | 0.76 | 29 | empty |
| 4 | 69 | 0.40 | 0.80 | 15 | empty |
| 5 | 66 | 0.33 | 0.75 | 18 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4DJH · Structure of the human kappa opioid receptor in complex with JDTic · an experimental structure of the same protein · chain A against B, TM-score 0.74
- 4DJH · Structure of the human kappa opioid receptor in complex with jdtic · an experimental structure of the same protein · chain A against B, TM-score 0.74
- 6VI4 · Nanobody-Enabled Monitoring of Kappa Opioid Receptor States · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 6VI4 · Nanobody-enabled monitoring of kappa opioid receptor states · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 7UL5 · CryoEM Structure of Inactive SSTR2 bound to Nb6 · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7UL5 · Cryoem structure of inactive SSTR2 bound to NB6 · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 8F7W · Gi bound kappa-opioid receptor in complex with dynorphin · an experimental structure of the same protein · chain A against R, TM-score 0.69
- 7UL2 · CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6 · an experimental structure of the same protein · chain A against R, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41145
- Elsewhere: UniProt P41145 · AlphaFold DB P41145
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