UniProt Q9UM73
ALK tyrosine kinase receptor (Q9UM73)
ALK tyrosine kinase receptor (UniProt Q9UM73), EC 2.7.10.1: 128 experimental structures and 1 predicted model on GenesisL1, 20 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9UM73
- Protein
- ALK tyrosine kinase receptor
- EC
- 2.7.10.1
- Experimental structures
- 128
- Predicted models
- 1
- Ligands
- 20
- Pockets
- 7 · 5 records with a druggable one
Structures
129 records of Q9UM73 in the MolNFT archive: 128 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KUP | Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589)… | solution nmr | B | — | — |
| 2KUP | Solution structure of the complex of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589)… | solution nmr | B | — | — |
| 2KUQ | Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589)… | solution nmr | A | — | — |
| 2KUQ | Solution structure of the chimera of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589)… | solution nmr | A | — | — |
| 2XB7 | Structure of Human Anaplastic Lymphoma Kinase in complex with NVP- TAE684 | x-ray diffraction | A | — | — |
| 2XB7 | Structure of human anaplastic lymphoma kinase in complex with nvp- TAE684 | x-ray diffraction | A | — | — |
| 2XBA | Structure of Human Anaplastic Lymphoma Kinase in complex with PHA- E429 | x-ray diffraction | A | — | — |
| 2XBA | Structure of human anaplastic lymphoma kinase in complex with pha-E429 | x-ray diffraction | A | — | — |
| 2YHV | Structure of L1196M Mutant Anaplastic Lymphoma Kinase | x-ray diffraction | A | — | — |
| 2YHV | Structure of L1196M mutant anaplastic lymphoma kinase | x-ray diffraction | A | — | — |
| 2YJR | Structure of F1174L Mutant Anaplastic Lymphoma Kinase | x-ray diffraction | A | — | — |
| 2YJR | Structure of F1174L mutant anaplastic lymphoma kinase | x-ray diffraction | A | — | — |
| 2YJS | Structure of C1156Y Mutant Anaplastic Lymphoma Kinase | x-ray diffraction | A | — | — |
| 2YJS | Structure of C1156Y mutant anaplastic lymphoma kinase | x-ray diffraction | A | — | — |
| 2YS5 | Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589)… | solution nmr | B | — | — |
| 2YS5 | Solution structure of the complex of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589)… | solution nmr | B | — | — |
| 2YT2 | Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589)… | solution nmr | A | — | — |
| 2YT2 | Solution structure of the chimera of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589)… | solution nmr | A | — | — |
| 3AOX | X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802 | x-ray diffraction | A | — | — |
| 3AOX | X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802 | x-ray diffraction | A | — | — |
| 3L9P | Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain | x-ray diffraction | A | — | — |
| 3L9P | Crystal structure of the anaplastic lymphoma kinase catalytic domain | x-ray diffraction | A | — | — |
| 3LCS | Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain | x-ray diffraction | A | — | — |
| 3LCS | Crystal structure of the anaplastic lymphoma kinase catalytic domain | x-ray diffraction | A | — | — |
| 3LCT | Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain | x-ray diffraction | A | — | — |
| 3LCT | Crystal structure of the anaplastic lymphoma kinase catalytic domain | x-ray diffraction | A | — | — |
| 4ANL | Structure of G1269A Mutant Anaplastic Lymphoma Kinase | x-ray diffraction | A | — | — |
| 4ANL | Structure of G1269A mutant anaplastic lymphoma kinase | x-ray diffraction | A | — | — |
| 4ANQ | Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib | x-ray diffraction | A | — | — |
| 4ANQ | Structure of G1269A mutant anaplastic lymphoma kinase in complex with crizotinib | x-ray diffraction | A | — | — |
| 4ANS | Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib | x-ray diffraction | A | — | — |
| 4ANS | Structure of L1196M,G1269A double mutant anaplastic lymphoma kinase in complex with crizotinib | x-ray diffraction | A | — | — |
| 4CCB | Structure of the Human Anaplastic Lymphoma Kinase in Complex with… | x-ray diffraction | A | — | — |
| 4CCB | Structure of the human anaplastic lymphoma kinase in complex with 3… | x-ray diffraction | A | — | — |
| 4CCU | Structure of the Human Anaplastic Lymphoma Kinase in Complex with… | x-ray diffraction | A | — | — |
| 4CCU | Structure of the human anaplastic lymphoma kinase in complex with 2… | x-ray diffraction | A | — | — |
| 4CD0 | Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with… | x-ray diffraction | A | — | — |
| 4CD0 | Structure of L1196M mutant human anaplastic lymphoma kinase in complex with… | x-ray diffraction | A | — | — |
| 4CLI | Structure of the Human Anaplastic Lymphoma Kinase in Complex with PF- 06463922… | x-ray diffraction | A | — | — |
| 4CLI | Structure of the human anaplastic lymphoma kinase in complex with pf- 06463922… | x-ray diffraction | A | — | — |
| 4CLJ | Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922… | x-ray diffraction | A | — | — |
| 4CLJ | Structure of L1196M mutant human anaplastic lymphoma kinase in complex with pf-06463922… | x-ray diffraction | A | — | — |
| 4CMO | Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor… | x-ray diffraction | A | — | — |
| 4CMO | Structure of the human anaplastic lymphoma kinase in complex with the inhibitor… | x-ray diffraction | A | — | — |
| 4CMT | Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor… | x-ray diffraction | A | — | — |
| 4CMT | Structure of the human anaplastic lymphoma kinase in complex with the inhibitor… | x-ray diffraction | A | — | — |
| 4CMU | Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor… | x-ray diffraction | A | — | — |
| 4CMU | Structure of the human anaplastic lymphoma kinase in complex with the inhibitor… | x-ray diffraction | A | — | — |
| 4CNH | Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor… | x-ray diffraction | A, B | — | — |
| 4CNH | Structure of the human anaplastic lymphoma kinase in complex with the inhibitor… | x-ray diffraction | A, B | — | — |
| 4CTB | Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor… | x-ray diffraction | A | — | — |
| 4CTB | Structure of the human anaplastic lymphoma kinase in complex with the inhibitor… | x-ray diffraction | A | — | — |
| 4CTC | Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor… | x-ray diffraction | A | — | — |
| 4CTC | Structure of the human anaplastic lymphoma kinase in complex with the inhibitor… | x-ray diffraction | A | — | — |
| 4DCE | Crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide… | x-ray diffraction | A, B | — | — |
| 4DCE | Crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide… | x-ray diffraction | A, B | — | — |
| 4FNW | Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain | x-ray diffraction | A | — | — |
| 4FNW | Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain | x-ray diffraction | A | — | — |
| 4FNX | Crystal structure of the apo R1275Q anaplastic lymphoma kinase catalytic domain | x-ray diffraction | A | — | — |
| 4FNX | Crystal structure of the apo R1275Q anaplastic lymphoma kinase catalytic domain | x-ray diffraction | A | — | — |
69 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- 6YL · 2-[(1~{R})-1-[2-azanyl-5-(1,3-dimethylpyrazol-4-yl) pyridin-3-yl]oxyethyl]-4-fluoranyl-~{N},~{N}-dimethyl-benzamide · in 2 records
- F8R · 2-(dimethylamino)-1-[5-methoxy-6-[[4-[(2-propan-2-ylsulfonylphenyl)amino]-5H-pyrrolo[3,2-d]pyrimidin-2-yl]amino]-2,3-dihydroindol-1-yl]ethanone · in 2 records
- J3Y · [6-{[(1S)-1-(5-fluoropyridin-2-yl)ethyl]amino}-1-(5-methyl-1H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl](morpholin-4-yl)methanone · in 2 records
- J4M · N-[(1S)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine · in 2 records
- 25J · 4-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1H-isoindol-1-one · in 1 record
- 34Y · 4-[(4-methylpiperazin-1-yl)methyl]-N-{3-[3-methyl-4-({[5-(propan-2-yl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-1H-pyrazol-5-yl}benzamide · in 1 record
- 6GY · 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine · in 1 record
- 729 · N-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1H-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide · in 1 record
- AWJ · (2R)-2-[5-(6-amino-5-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol · in 1 record
- CZ4 · 5-chloro-N~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1H-pyrazol-4-yl}pyrimidine-2,4-diamine · in 1 record
- HKJ · N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-1-(5-methyl-1H-pyrazol-3-yl)-3-[(oxetan-3-yl)sulfonyl]-1H-pyrrolo[2, 3-b]pyridin-6-amine · in 1 record
- NI · Nickel (II) ion · in 1 record
- U4W · N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-2-[(4-hydroxycyclohexyl)amino]-4-(4-methylpiperazin-1-yl) benzamide · in 1 record
- VGH · 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine · in 1 record
- VRM · 3-(3-methyl-1H-pyrazol-5-yl)pyridine · in 1 record
- VTA · 4-{[(1R,2R)-2-(2,4-difluorophenyl)cyclopropyl]oxy}-3-(5-methyl-1H-pyrazol-3-yl)benzonitrile · in 1 record
- VTD · 3-(3-chlorophenyl)-5-methyl-1H-pyrazole · in 1 record
- W47 · 1-{(1S,2S)-1-(2,4-difluorophenyl)-2-[2-(3-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl) phenoxy]cyclopropyl}methanamine · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 2XB7 chain A against the predicted model Q9UM73: TM-score 0.99, RMSD 0.63 Å
- 2XB7 chain A against the predicted model Q9UM73: TM-score 0.99, RMSD 0.63 Å
- 6MX8 chain A against the predicted model Q9UM73: TM-score 0.99, RMSD 0.71 Å
- 4FNZ chain A against the predicted model Q9UM73: TM-score 0.99, RMSD 0.82 Å
- 4FNZ chain A against the predicted model Q9UM73: TM-score 0.99, RMSD 0.82 Å
- 4DCE chain B against the predicted model Q9UM73: TM-score 0.99, RMSD 0.84 Å
- 4DCE chain B against the predicted model Q9UM73: TM-score 0.99, RMSD 0.84 Å
- 4DCE chain A against the predicted model Q9UM73: TM-score 0.99, RMSD 0.86 Å
- 4DCE chain A against the predicted model Q9UM73: TM-score 0.99, RMSD 0.86 Å
- 6EDL chain A against the predicted model Q9UM73: TM-score 0.99, RMSD 0.82 Å
Elsewhere
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