GL1X · GenesisL1 explorer

Ligand · AWF

AWF · 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol

AWF, 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol (C22 H23 F N6 O2 S, 454.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
AWF
Formula
C22 H23 F N6 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

AWF in 2 structures; the first of them:

  • 4CCU · Structure of the Human Anaplastic Lymphoma Kinase in Complex with… · AWF A1500 · binds LEU1122, GLY1123, VAL1130, ALA1148, LYS1150, VAL1180, LEU1196, GLU1197 and 11 more
  • 4CCU · Structure of the human anaplastic lymphoma kinase in complex with 2… · AWF A1500 · binds LEU1122, GLY1123, VAL1130, ALA1148, LYS1150, VAL1180, LEU1196, GLU1197 and 11 more

Residues it binds most

LEU 2, GLY 2, ASP 2, VAL 2, ALA 2, ARG 2, ASN 2, CYS 2, GLU 2, LYS 2 (residue and the binding sites it lines).

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