Ligand · IV7
IV7 · (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one
IV7, (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one (C21 H22 F N5 O2, 395.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1…
- Component
- IV7
- Formula
- C21 H22 F N5 O2
- Class
- ligand
- Structures
- 2
- PDB entries
- 1
Binding sites
IV7 in 2 structures; the first of them:
- 4CMU · Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor… · IV7 A2401 · binds LEU1122, VAL1130, ALA1148, LYS1150, VAL1180, LEU1196, GLU1197, LEU1198 and 10 more
- 4CMU · Structure of the human anaplastic lymphoma kinase in complex with the inhibitor… · IV7 A2401 · binds LEU1122, VAL1130, ALA1148, LYS1150, VAL1180, LEU1196, GLU1197, LEU1198 and 10 more
Residues it binds most
LEU 2, ALA 2, ASP 2, GLY 2, VAL 2, ARG 2, ASN 2, CYS 2, GLU 2, LYS 2 (residue and the binding sites it lines).
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