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Ligand · KVC

KVC · (5R)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20-tetrahydro-11,7-(azeno)pyrido[2',1':2,3]imidazo[4,5-h][2,5,11]benzoxadiazacyclotetradecine-14-carbonitrile

KVC, (5R)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20-tetrahydro-11,7-(azeno)pyrido[2',1':2,3]imidazo[4,5-h][2,5,11]benzoxadiazacyclotetradecine-14-carbonitrile (C23 H18 F N7 O2, 443.4 g/mol), in the MolNFT structures on GenesisL1…

Component
KVC
Formula
C23 H18 F N7 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

KVC in 2 structures; the first of them:

  • 4CTB · Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor… · KVC A2402 · binds ARG1120, LEU1122, GLY1123, VAL1130, GLU1132, ALA1148, LYS1150, VAL1180 and 13 more
  • 4CTB · Structure of the human anaplastic lymphoma kinase in complex with the inhibitor… · KVC A2402 · binds ARG1120, LEU1122, GLY1123, VAL1130, GLU1132, ALA1148, LYS1150, VAL1180 and 13 more

Residues it binds most

LEU 2, GLY 2, ALA 2, ARG 2, ASP 2, GLU 2, VAL 2, ASN 2, CYS 2, LYS 2 (residue and the binding sites it lines).

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