UniProt Q9QUK6
Toll-like receptor 4 (Q9QUK6)
Toll-like receptor 4 (UniProt Q9QUK6), EC 3.2.2.6: 17 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9QUK6
- Protein
- Toll-like receptor 4
- EC
- 3.2.2.6
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 52 · 5 records with a druggable one
Structures
18 records of Q9QUK6 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Z64 | Crystal structure of mouse TLR4 and mouse MD-2 complex | x-ray diffraction | A | — | — |
| 2Z64 | Crystal structure of mouse TLR4 and mouse md-2 complex | x-ray diffraction | A | — | — |
| 3VQ1 | Crystal structure of mouse TLR4/MD-2/lipid IVa complex | x-ray diffraction | A, B | — | — |
| 3VQ1 | Crystal structure of mouse TLR4/MD-2/LIPID iva complex | x-ray diffraction | A, B | — | — |
| 3VQ2 | Crystal structure of mouse TLR4/MD-2/LPS complex | x-ray diffraction | A, B | — | — |
| 3VQ2 | Crystal structure of mouse TLR4/MD-2/LPS complex | x-ray diffraction | A, B | — | — |
| 5IJB | The ligand-free structure of the mouse TLR4/MD-2 complex | x-ray diffraction | A, B | NAG | — |
| 5IJB | The ligand-free structure of the mouse TLR4/MD-2 complex | x-ray diffraction | A, B | — | — |
| 5IJC | The crystal structure of mouse TLR4/MD-2/neoseptin-3 complex | x-ray diffraction | A, B | NAG, V2A | — |
| 5IJC | The crystal structure of mouse TLR4/MD-2/NEOSEPTIN-3 complex | x-ray diffraction | A, B | — | — |
| 5IJD | The crystal structure of mouse TLR4/MD-2/lipid A complex | x-ray diffraction | A, B | NAG, LP4, LP5, MYR | 8 (best 0.80) |
| 5IJD | The crystal structure of mouse TLR4/MD-2/LIPID a complex | x-ray diffraction | A, B | — | — |
| 7MLM | Crystal structure of mouse TLR4/MD-2 in complex with sulfatides | x-ray diffraction | A | NAG, ZKM | 2 (best 0.69) |
| 7MLM | Crystal structure of mouse TLR4/MD-2 in complex with sulfatides | x-ray diffraction | A | NAG, ZKM | — |
| 8WQT | Cryo-EM Structure of Mouse TLR4/MD-2/DLAM1 complex | electron microscopy | B, A | NAG, X6Z, GP4, 0IL | 11 (best 0.78) |
| 8WRY | Cryo-EM Structure of Mouse TLR4/MD-2/DLAM3 Complex | electron microscopy | B, A | NAG, 0IL, 2IL, XIQ, GP4 | 12 (best 0.78) |
| 8WSA | Cryo-EM Structure of Mouse TLR4/MD-2/DLAM5 Complex | electron microscopy | A, B | X6N, A1L01, NAG, GP4 | 18 (best 0.88) |
| Q9QUK6 | AlphaFold monomer V2.0 prediction for toll-like receptor 4 (Q9QUK6) | predicted | A | — | 1 (best 0.31) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- GP4 · 2-amino-2-deoxy-4-O-phosphono-alpha-D-glucopyranose · in 3 records
- 0IL · (3R)-3-(tetradecanoyloxy)tetradecanoic acid · in 2 records
- ZKM · N-[(1S,2R,3E)-2-hydroxy-1-{[(3-O-sulfo-beta-D-galactopyranosyl)oxy]methyl}heptadec-3-en-1-yl]-hexadecanamide · in 2 records
- 2IL · (3R)-3-(dodecanoyloxy)tetradecanoic acid · in 1 record
- A1L01 · (3~{S})-3-decanoyloxytetradecanoic acid · in 1 record
- LP4 · 2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-4-O-phosphono-beta-D-glucopyranose · in 1 record
- LP5 · (R)-((2R,3S,4R,5R,6R)-3-hydroxy-2-(hydroxymethyl)-5-((R)-3-hydroxytetradecanamido)-6-(phosphonooxy) tetrahydro-2H-pyran-4-yl) 3-hydroxytetradecanoate · in 1 record
- MYR · Myristic acid · in 1 record
- V2A · neoseptin 3 · in 1 record
- X6N · [(2~{R},3~{S},4~{R},5~{S})-2-(hydroxymethyl)-5-methoxy-4,6-bis(oxidanyl)oxan-3-yl] dihydrogen phosphate · in 1 record
- X6Z · [(2~{R},3~{S},4~{S},5~{S})-5-methoxy-3,4,6-tris(oxidanyl)oxan-2-yl]methyl dihydrogen phosphate · in 1 record
- XIQ · 2-(hydroxymethyl)-5-methoxy-3,6-bis(oxidanyl)pyran-4-one · in 1 record
Experiment against prediction
- 3VQ2 chain A against the predicted model Q9QUK6: TM-score 0.99, RMSD 0.64 Å
- 3VQ2 chain A against the predicted model Q9QUK6: TM-score 0.99, RMSD 0.64 Å
- 3VQ1 chain A against the predicted model Q9QUK6: TM-score 0.99, RMSD 0.83 Å
- 3VQ1 chain A against the predicted model Q9QUK6: TM-score 0.99, RMSD 0.83 Å
- 7MLM chain A against the predicted model Q9QUK6: TM-score 0.99, RMSD 0.94 Å
- 7MLM chain A against the predicted model Q9QUK6: TM-score 0.99, RMSD 0.94 Å
- 5IJC chain A against the predicted model Q9QUK6: TM-score 0.99, RMSD 0.95 Å
- 5IJC chain A against the predicted model Q9QUK6: TM-score 0.99, RMSD 0.95 Å
- 5IJD chain A against the predicted model Q9QUK6: TM-score 0.99, RMSD 1.00 Å
- 5IJD chain A against the predicted model Q9QUK6: TM-score 0.99, RMSD 1.00 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.