UniProt Q9NY97
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (Q9NY97)
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (UniProt Q9NY97), EC 2.4.1.149: 19 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 97 pockets. Binding sites, druggability and…
- UniProt
- Q9NY97
- Protein
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
- EC
- 2.4.1.149
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 97 · 10 records with a druggable one
Structures
20 records of Q9NY97 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6WMM | Human poly-N-acetyl-lactosamine synthase structure demonstrates a modular assembly of catalytic… | x-ray diffraction | A, B | NAG, BMA, MG, UDP | — |
| 6WMN | Human poly-N-acetyl-lactosamine synthase structure demonstrates a modular assembly of catalytic… | x-ray diffraction | A, B, C, D | NAG, BMA, MAN, MG, UDP, CL | 12 (best 0.75) |
| 6WMN | Human poly-N-acetyl-lactosamine synthase structure demonstrates a modular assembly of catalytic… | x-ray diffraction | A, B, C, D | NAG, BMA, MG, UDP, CL | — |
| 6WMO | Human poly-N-acetyl-lactosamine synthase structure demonstrates a modular assembly of catalytic… | x-ray diffraction | A, B | GAL, NAG, BMA, MG, UDP | 4 (best 0.77) |
| 6WMO | Human poly-N-acetyl-lactosamine synthase structure demonstrates a modular assembly of catalytic… | x-ray diffraction | A, B | GAL, NAG, BMA, MG, UDP | — |
| 7JHI | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 iodide-derivative | x-ray diffraction | A, B, C, D | NAG, BMA, MAN, MG, UDP, IOD | 15 (best 0.73) |
| 7JHI | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 iodide- derivative | x-ray diffraction | A, B, C, D | NAG, BMA, MAN, MG, UDP, IOD | — |
| 7JHK | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 in unliganded form | x-ray diffraction | A, B, C, D | NAG, BMA, MAN, CL, NA | 19 (best 0.66) |
| 7JHK | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 in unliganded form | x-ray diffraction | A, B, C, D | NAG, BMA, MAN, CL, NA | — |
| 7JHL | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with UDP-N-acetylglucosamine | x-ray diffraction | A, B | NAG, BMA, MAN, UD1, MG, CL | 8 (best 0.68) |
| 7JHL | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with udp-N-acetylglucosamine | x-ray diffraction | A, B | NAG, BMA, MAN, UD1, MG, CL | — |
| 7JHM | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with N-acetyl-lactosamine | x-ray diffraction | A, B | NAG, BMA, MAN, GAL | 8 (best 0.58) |
| 7JHM | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with N- acetyl-lactosamine | x-ray diffraction | A, B | NAG, BMA, MAN, GAL | — |
| 7JHN | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with UDP and trisaccharide… | x-ray diffraction | A | NAG, BMA, MAN, GAL, MG, UDP | 3 (best 0.61) |
| 7JHN | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with udp and trisaccharide… | x-ray diffraction | A | NAG, BMA, MAN, GAL, MG, UDP | — |
| 7JHO | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with UDP | x-ray diffraction | A, B | NAG, BMA, MAN, FUC, UDP, MG | 9 (best 0.56) |
| 7JHO | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with udp | x-ray diffraction | A, B | NAG, BMA, MAN, FUC, UDP, MG | — |
| 8SZ3 | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 7j | x-ray diffraction | A, B | NAG, X18 | 8 (best 0.57) |
| 8TIC | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 1 | x-ray diffraction | A, B, C, D | NAG, BMA, MAN, FKX, CL | 11 (best 0.72) |
| Q9NY97 | AlphaFold monomer V2.0 prediction for N-acetyllactosaminide… | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 19 records
- BMA · beta-D-mannopyranose · in 18 records
- MAN · alpha-D-mannopyranose · in 14 records
- CL · Chloride ion · in 13 records
- MG · Magnesium ion · in 13 records
- UDP · Uridine-5'-diphosphate · in 11 records
- GAL · beta-D-galactopyranose · in 6 records
- FUC · alpha-L-fucopyranose · in 2 records
- IOD · Iodide ion · in 2 records
- NA · Sodium ion · in 2 records
- UD1 · Uridine-diphosphate-N-acetylglucosamine · in 2 records
- FKX · 3-(2-methylpropyl)-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxylic acid · in 1 record
- X18 · N-[(1S)-1-(5-bromopyridin-2-yl)ethyl]-3-[(2R)-3,3-dimethylbutan-2-yl]-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxamide · in 1 record
Experiment against prediction
- 6WMM chain A against the predicted model Q9NY97: TM-score 1.00, RMSD 0.34 Å
- 7JHI chain B against the predicted model Q9NY97: TM-score 1.00, RMSD 0.40 Å
- 7JHI chain B against the predicted model Q9NY97: TM-score 1.00, RMSD 0.40 Å
- 6WMN chain B against the predicted model Q9NY97: TM-score 1.00, RMSD 0.40 Å
- 6WMN chain B against the predicted model Q9NY97: TM-score 1.00, RMSD 0.40 Å
- 7JHK chain B against the predicted model Q9NY97: TM-score 1.00, RMSD 0.44 Å
- 7JHK chain B against the predicted model Q9NY97: TM-score 1.00, RMSD 0.44 Å
- 7JHK chain C against the predicted model Q9NY97: TM-score 1.00, RMSD 0.47 Å
- 7JHK chain C against the predicted model Q9NY97: TM-score 1.00, RMSD 0.47 Å
- 7JHO chain A against the predicted model Q9NY97: TM-score 1.00, RMSD 0.45 Å
Elsewhere
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