UniProt Q9C0B1
Q9C0B1
Q9C0B1 (UniProt Q9C0B1): 39 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9C0B1
- Experimental structures
- 39
- Predicted models
- 1
- Ligands
- 13
Structures
40 records of Q9C0B1 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3LFM | Crystal structure of the fat mass and obesity associated (FTO) protein reveals basis for its… | x-ray diffraction | A | — | — |
| 3LFM | Crystal structure of the fat mass and obesity associated (fto) protein reveals basis for its… | x-ray diffraction | A | — | — |
| 4CXW | Crystal structure of human FTO in complex with subfamily-selective inhibitor 12 | x-ray diffraction | A | — | — |
| 4CXW | Crystal structure of human fto in complex with subfamily-selective inhibitor 12 | x-ray diffraction | A | — | — |
| 4CXX | Crystal structure of human FTO in complex with acylhydrazine inhibitor 16 | x-ray diffraction | A | — | — |
| 4CXX | Crystal structure of human fto in complex with acylhydrazine inhibitor 16 | x-ray diffraction | A | — | — |
| 4CXY | Crystal structure of human FTO in complex with acylhydrazine inhibitor 21 | x-ray diffraction | A | — | — |
| 4CXY | Crystal structure of human fto in complex with acylhydrazine inhibitor 21 | x-ray diffraction | A | — | — |
| 4IDZ | Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with… | x-ray diffraction | A | — | — |
| 4IDZ | Crystal structure of the human fat mass and obesity associated protein (fto) in complex with… | x-ray diffraction | A | — | — |
| 4IE0 | Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with… | x-ray diffraction | A | — | — |
| 4IE0 | Crystal structure of the human fat mass and obesity associated protein (fto) in complex with… | x-ray diffraction | A | — | — |
| 4IE4 | Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with… | x-ray diffraction | A | — | — |
| 4IE4 | Crystal structure of the human fat mass and obesity associated protein (fto) in complex with… | x-ray diffraction | A | — | — |
| 4IE5 | Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with… | x-ray diffraction | A | — | — |
| 4IE5 | Crystal structure of the human fat mass and obesity associated protein (fto) in complex with… | x-ray diffraction | A | — | — |
| 4IE6 | Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with… | x-ray diffraction | A | — | — |
| 4IE6 | Crystal structure of the human fat mass and obesity associated protein (fto) in complex with… | x-ray diffraction | A | — | — |
| 4IE7 | Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with… | x-ray diffraction | A | — | — |
| 4IE7 | Crystal structure of the human fat mass and obesity associated protein (fto) in complex with… | x-ray diffraction | A | — | — |
| 4QHO | Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with CCO10 | x-ray diffraction | A | — | — |
| 4QHO | Crystal structure of the human fat mass and obesity associated protein (fto) in complex with CCO10 | x-ray diffraction | A | — | — |
| 4QKN | Crystal structure of FTO bound to a selective inhibitor | x-ray diffraction | A | — | — |
| 4QKN | Crystal structure of fto bound to a selective inhibitor | x-ray diffraction | A | — | — |
| 4ZS2 | Structural complex of FTO/FLUORESCEIN | x-ray diffraction | A | — | — |
| 4ZS3 | Structural complex of 5-aminofluorescein bound to the FTO protein | x-ray diffraction | A | — | — |
| 4ZS3 | Structural complex of 5-aminofluorescein bound to the fto protein | x-ray diffraction | A | — | — |
| 5DAB | Crystal structure of fto-IN115 | x-ray diffraction | A | — | — |
| 5F8P | A Novel Inhibitor of the Obesity-Related Protein FTO | x-ray diffraction | A | SO4, FIJ, AKG, FE2 | — |
| 5F8P | A novel inhibitor of the obesity-related protein fto | x-ray diffraction | A | — | — |
| 5ZMD | Crystal structure of FTO in complex with m6dA modified ssDNA | x-ray diffraction | A, C, E, G | MN, OGA | — |
| 5ZMD | Crystal structure of fto in complex with M6DA modified ssdna | x-ray diffraction | A, C, E, G | MN, OGA | — |
| 6AEJ | Crystal structure of human FTO in complex with small-molecule inhibitors | x-ray diffraction | A | 7YC, ZN | — |
| 6AEJ | Crystal structure of human fto in complex with small-molecule inhibitors | x-ray diffraction | A | 7YC, ZN | — |
| 6AK4 | Crystal structure of human fto in complex with small-molecule inhibitors | x-ray diffraction | A | ZN, PD9 | — |
| 6AKW | Crystal structure of RNA dioxygenase bound with an inhibitor | x-ray diffraction | A | AKG, 8S3 | — |
| 7CKK | Structural complex of fto bound with DAC51 | x-ray diffraction | A | OGA, B6C | — |
| 7E8Z | Crystal structure of the human fat mass and obesity associated protein (fto) in complex with SS81 | x-ray diffraction | A | ZN, HZX | — |
| 7WCV | Co-crystal structure of fto bound to 6E | x-ray diffraction | A | AKG, MN, 943 | — |
| Q9C0B1 | AlphaFold monomer V2.0 prediction for alpha-ketoglutarate-dependent dioxygenase fto (Q9C0B1) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 4 records
- AKG · 2-oxoglutaric acid · in 3 records
- MN · Manganese (II) ion · in 3 records
- OGA · N-oxalylglycine · in 3 records
- 7YC · (E)-3-[3-nitro-4,5-bis(oxidanyl)phenyl]-2-(1,3-oxazinan-3-ylcarbonyl)prop-2-enenitrile · in 2 records
- 8S3 · 2-[[2,6-bis(chloranyl)-4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]amino]benzoic acid · in 1 record
- 943 · 2-[[2,6-bis(chloranyl)-4-pyridin-4-yl-phenyl]amino]benzoic acid · in 1 record
- B6C · 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl) phenyl]amino}-N-hydroxybenzamide · in 1 record
- FE2 · Fe (II) ion · in 1 record
- FIJ · 4-chloranyl-6-[(2~{S})-6-chloranyl-2,4,4-trimethyl-7-oxidanyl-3~{H}-chromen-2-yl]benzene-1,3-diol · in 1 record
- HZX · 2-[[6-[(4-nitrophenyl)amino]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid · in 1 record
- PD9 · (~{E})-2-cyano-~{N},~{N}-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 4QKN chain A against the predicted model Q9C0B1: TM-score 1.00, RMSD 0.45 Å
- 4QKN chain A against the predicted model Q9C0B1: TM-score 1.00, RMSD 0.45 Å
- 4IE4 chain A against the predicted model Q9C0B1: TM-score 1.00, RMSD 0.49 Å
- 4IE4 chain A against the predicted model Q9C0B1: TM-score 1.00, RMSD 0.49 Å
- 4IE7 chain A against the predicted model Q9C0B1: TM-score 1.00, RMSD 0.49 Å
- 4IE7 chain A against the predicted model Q9C0B1: TM-score 1.00, RMSD 0.49 Å
- 4QHO chain A against the predicted model Q9C0B1: TM-score 1.00, RMSD 0.53 Å
- 4QHO chain A against the predicted model Q9C0B1: TM-score 1.00, RMSD 0.53 Å
- 4IDZ chain A against the predicted model Q9C0B1: TM-score 1.00, RMSD 0.55 Å
- 4IDZ chain A against the predicted model Q9C0B1: TM-score 1.00, RMSD 0.55 Å
Elsewhere
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