UniProt Q99IB8
RNA-directed RNA polymerase (Q99IB8)
RNA-directed RNA polymerase (UniProt Q99IB8), EC 2.7.7.48: 50 experimental structures on GenesisL1, 11 ligands bound, 240 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q99IB8
- Protein
- RNA-directed RNA polymerase
- EC
- 2.7.7.48
- Experimental structures
- 50
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 240 · 41 records with a druggable one
Structures
50 records of Q99IB8 in the MolNFT archive: 50 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KZQ | s34r Structure | solution nmr | A | — | — |
| 2KZQ | S34R structure | solution nmr | A | — | — |
| 2LIF | Solution Structure of KKGF | solution nmr | A | — | — |
| 2LIF | Solution structure of kkgf | solution nmr | A | — | — |
| 2LVG | NMR structure of HCV Non-structural protein AB, NS4B(1-40) | solution nmr | A | — | — |
| 2LVG | NMR structure of HCV non-structural protein ab, NS4B(1-40) | solution nmr | A | — | — |
| 2XXD | HCV-JFH1 NS5B polymerase structure at 1.9 angstrom | x-ray diffraction | A | PO4 | 6 (best 0.80) |
| 2XXD | HCV-JFH1 NS5B polymerase structure at 1.9 ångström | x-ray diffraction | A | PO4 | 6 (best 0.80) |
| 2XYM | HCV-JFH1 NS5B T385A mutant | x-ray diffraction | A | PO4 | 4 (best 0.79) |
| 2XYM | HCV-JFH1 NS5B T385A mutant | x-ray diffraction | A | PO4 | 4 (best 0.79) |
| 3I5K | Crystal structure of the NS5B polymerase from Hepatitis C Virus (HCV) strain JFH1 | x-ray diffraction | A, B, C, D | PO4 | 20 (best 0.80) |
| 3I5K | Crystal structure of the NS5B polymerase from hepatitis C virus (HCV) strain JFH1 | x-ray diffraction | A, B, C, D | PO4 | 20 (best 0.80) |
| 4AEP | HCV-JFH1 NS5B polymerase structure at 1.8 ångström | x-ray diffraction | A | PO4 | 6 (best 0.80) |
| 4AEP | HCV-JFH1 NS5B polymerase structure at 1.8 ångström | x-ray diffraction | A | PO4 | 6 (best 0.80) |
| 4AEX | HCV-JFH1 NS5B POLYMERASE STRUCTURE AT 2.4 ANGSTROM in a primitive orthorhombic space group | x-ray diffraction | A, B | — | 11 (best 0.81) |
| 4AEX | HCV-JFH1 NS5B polymerase structure at 2.4 ångström in a primitive orthorhombic space group | x-ray diffraction | A, B | — | 11 (best 0.81) |
| 4E76 | Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion | x-ray diffraction | A | SO4 | 6 (best 0.62) |
| 4E76 | Apo crystal structure of HCV NS5B genotype 2A jfh-1 isolate with beta hairpin loop deletion | x-ray diffraction | A | SO4 | 6 (best 0.62) |
| 4E78 | Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta… | x-ray diffraction | A | — | 5 (best 0.78) |
| 4E78 | Crystal structure of a product state assembly of HCV NS5B genotype 2A jfh-1 isolate with beta… | x-ray diffraction | A | — | 5 (best 0.78) |
| 4E7A | Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta… | x-ray diffraction | A | — | 5 (best 0.76) |
| 4E7A | Crystal structure of a product state assembly of HCV NS5B genotype 2A jfh-1 isolate with beta… | x-ray diffraction | A | — | 5 (best 0.76) |
| 4J1V | Functional and structural studies of MOBKL1B, a Salvador/Warts/Hippo tumor suppressor pathway, in… | x-ray diffraction | E, G, F, H | — | — |
| 4J1V | Functional and structural studies of MOBKL1B, a SALVADOR/WARTS/HIPPO tumor suppressor pathway, in… | x-ray diffraction | E, G, F, H | — | — |
| 4OBC | Crystal structure of HCV polymerase NS5b genotype 2a JFH-1 isolate with the S15G, C223H, V321I… | x-ray diffraction | A | CL | 3 (best 0.75) |
| 4OBC | Crystal structure of HCV polymerase NS5B genotype 2A jfh-1 isolate with the S15G, C223H, V321I… | x-ray diffraction | A | CL | 3 (best 0.75) |
| 4WT9 | Apo crystal structure of HCV NS5B genotype 2A jfh-1 isolate with E86Q E87Q S15G C223H V321I and… | x-ray diffraction | A | CL | 6 (best 0.64) |
| 4WT9 | Apo crystal structure of HCV NS5B genotype 2A jfh-1 isolate with E86Q E87Q S15G C223H V321I and… | x-ray diffraction | A | CL | 6 (best 0.64) |
| 4WTA | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, UDP | 3 (best 0.76) |
| 4WTA | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, UDP | 3 (best 0.76) |
| 4WTC | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, CDP | 4 (best 0.78) |
| 4WTD | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, ADP, CL | 4 (best 0.77) |
| 4WTD | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, ADP, CL | 4 (best 0.77) |
| 4WTE | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, GDP | 4 (best 0.77) |
| 4WTE | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, GDP | 4 (best 0.77) |
| 4WTF | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, 5GS | 4 (best 0.80) |
| 4WTF | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, 5GS | 4 (best 0.80) |
| 4WTG | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, 6GS, CL | 4 (best 0.79) |
| 4WTG | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, 6GS, CL | 4 (best 0.79) |
| 4WTI | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, GDP | 4 (best 0.75) |
| 4WTI | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, GDP | 4 (best 0.75) |
| 4WTJ | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, ADP | 5 (best 0.77) |
| 4WTJ | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, ADP | 5 (best 0.77) |
| 4WTK | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, CDP | 5 (best 0.77) |
| 4WTK | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, CDP | 5 (best 0.77) |
| 4WTL | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, UDP | 7 (best 0.74) |
| 4WTM | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, UDP | 6 (best 0.77) |
| 4WTM | Crystal structure of HCV NS5B genotype 2A jfh-1 isolate with S15G E86Q E87Q C223H V321I mutations… | x-ray diffraction | A | MN, CL, UDP | 6 (best 0.77) |
| 5TWM | CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA… | x-ray diffraction | A | 7NG, SO4 | 7 (best 0.84) |
| 5TWM | Crystal structure of the hepatitis C virus genotype 2A strain JFH1 L30S NS5B RNA-dependent RNA… | x-ray diffraction | A | 7NG, SO4 | — |
Ligands
- CL · Chloride ion · in 24 records
- MN · Manganese (II) ion · in 20 records
- PO4 · Phosphate ion · in 8 records
- UDP · Uridine-5'-diphosphate · in 5 records
- ADP · Adenosine-5'-diphosphate · in 4 records
- GDP · Guanosine-5'-diphosphate · in 4 records
- SO4 · Sulfate ion · in 4 records
- CDP · Cytidine-5'-diphosphate · in 3 records
- 5GS · 2'-C-methyluridine 5'-(trihydrogen diphosphate) · in 2 records
- 6GS · 2'-deoxy-2'-fluoro-2'-methyluridine 5'-(trihydrogen diphosphate) · in 2 records
- 7NG · 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide · in 2 records
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.