MolNFT v1 · #95820 · protein
Functional and structural studies of MOBKL1B, a SALVADOR/WARTS/HIPPO tumor suppressor pathway, in HCV replication
4J1V · Mob kinase activator 1A: “Functional and structural studies of MOBKL1B, a SALVADOR/WARTS/HIPPO tumor suppressor pathway, in HCV…”. X-ray diffraction, 1 ligand (ZN). MolNFT v1 #95820 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4J1V
- Type
- protein
- Length
- 380 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mob kinase activator 1A; NS5A domain II peptide
- UniProt
- Q9H8S9, Q99IB8
- Ligands
- ZN
Structure
x-ray diffraction · 3 distinct chains · 55% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Mob kinase activator 1A | protein | 166 | 61% helix, 2% strand | Q9H8S9 |
| E, F | NS5A domain II peptide | protein | 9 | 0% helix, 11% strand | Q99IB8 |
| G, H | NS5A domain II peptide | protein | 15 | 20% helix, 0% strand | Q99IB8 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
4 interfaces between chains.
- C–F · 614 Ų buried · 6 hydrogen bonds · protein-protein
- A–E · 612 Ų buried · 6 hydrogen bonds · protein-protein
- A–G · 559 Ų buried · 6 hydrogen bonds · protein-protein
- C–H · 557 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4J1V · Functional and structural studies of MOBKL1B, a Salvador/Warts/Hippo tumor suppressor… · the same entry in another collection · chain E against E, TM-score 1.00
- Q9H8S9 · AlphaFold monomer V2.0 prediction for mob kinase activator 1A (Q9H8S9) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H8S9
- Every structure of UniProt Q99IB8
- Elsewhere: RCSB PDB 4J1V · PDBe 4J1V · UniProt Q9H8S9 · UniProt Q99IB8
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