UniProt Q94C74
Serine hydroxymethyltransferase 2, mitochondrial (Q94C74)
Serine hydroxymethyltransferase 2, mitochondrial (UniProt Q94C74), EC 2.1.2.1: 5 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 20 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q94C74
- Protein
- Serine hydroxymethyltransferase 2, mitochondrial
- EC
- 2.1.2.1
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 20 · 1 record with a druggable one
Structures
6 records of Q94C74 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6SMN | A. thaliana serine hydroxymethyltransferase isoform 2 (ATSHMT2) in complex with methotrexate | x-ray diffraction | A, B, C, D | — | — |
| 6SMW | A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with pemetrexed | x-ray diffraction | A, B, C, D | PLS, LYA, SER, PLP | 20 (best 0.79) |
| 6SMW | A. thaliana serine hydroxymethyltransferase isoform 2 (ATSHMT2) in complex with pemetrexed | x-ray diffraction | A, B, C, D | LYA, PLP | — |
| 7PZZ | Crystal structure of serine hydroxymethyltransferase, isoform 2 from Arabidopsis thaliana (SHM2) | x-ray diffraction | A, B, C, D | CL, SO4 | — |
| 7PZZ | Crystal structure of serine hydroxymethyltransferase, isoform 2 from arabidopsis thaliana (SHM2) | x-ray diffraction | A, B, C, D | CL, SO4 | — |
| Q94C74 | AlphaFold monomer V2.0 prediction for serine hydroxymethyltransferase 2, mitochondrial (Q94C74) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 2 records
- LYA · 2-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid · in 2 records
- PLP · Pyridoxal-5'-phosphate · in 2 records
- SO4 · Sulfate ion · in 2 records
- PLS · [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine · in 1 record
- SER · Serine · in 1 record
Experiment against prediction
- 6SMW chain C against the predicted model Q94C74: TM-score 1.00, RMSD 0.32 Å
- 7PZZ chain A against the predicted model Q94C74: TM-score 1.00, RMSD 0.42 Å
- 7PZZ chain A against the predicted model Q94C74: TM-score 1.00, RMSD 0.42 Å
- 6SMW chain A against the predicted model Q94C74: TM-score 1.00, RMSD 0.45 Å
- 7PZZ chain C against the predicted model Q94C74: TM-score 1.00, RMSD 0.47 Å
- 7PZZ chain C against the predicted model Q94C74: TM-score 1.00, RMSD 0.47 Å
- 6SMW chain A against the predicted model Q94C74: TM-score 0.99, RMSD 0.45 Å
- 6SMW chain D against the predicted model Q94C74: TM-score 0.99, RMSD 0.59 Å
- 6SMW chain D against the predicted model Q94C74: TM-score 0.99, RMSD 0.59 Å
- 6SMW chain C against the predicted model Q94C74: TM-score 0.99, RMSD 0.32 Å
Elsewhere
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