MolNFT v1 · #164087 · protein
A. thaliana serine hydroxymethyltransferase isoform 2 (ATSHMT2) in complex with pemetrexed
6SMW: “A. thaliana serine hydroxymethyltransferase isoform 2 (ATSHMT2) in complex with pemetrexed”. X-ray diffraction, 2 ligands (LYA, PLP). MolNFT v1 #164087 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6SMW
- Type
- protein
- Length
- 1,909 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q94C74
- Ligands
- LYA, PLP
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 476 | — | Q94C74 |
| C | — | protein | 477 | — | Q94C74 |
| D | — | protein | 480 | — | Q94C74 |
Ligands and binding sites
- LYA · 2-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid · ligand · 3 copies · chains A, B, C, D
- PLP · Pyridoxal-5'-phosphate · ligand · chains C, D
- EDO · 1,2-ethanediol · additive · 38 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6SMW · A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with pemetrexed · the same entry in another collection · chain D against D, TM-score 1.00
- Q94C74 · AlphaFold monomer V2.0 prediction for serine hydroxymethyltransferase 2, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94C74
- Elsewhere: RCSB PDB 6SMW · PDBe 6SMW · UniProt Q94C74
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