UniProt Q91XB0
Three-prime repair exonuclease 1 (Q91XB0)
Three-prime repair exonuclease 1 (UniProt Q91XB0), EC 3.1.11.2: 41 experimental structures on GenesisL1, 14 ligands bound, 58 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q91XB0
- Protein
- Three-prime repair exonuclease 1
- EC
- 3.1.11.2
- Experimental structures
- 41
- Predicted models
- 0
- Ligands
- 14
- Pockets
- 58 · 10 records with a druggable one
Structures
41 records of Q91XB0 in the MolNFT archive: 41 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IOC | The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II… | x-ray diffraction | B, A | — | — |
| 2IOC | The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II… | x-ray diffraction | B, A | — | — |
| 2O4G | Structure of TREX1 in complex with a nucleotide | x-ray diffraction | A, B, C, D | — | — |
| 2O4G | Structure of TREX1 in complex with a nucleotide | x-ray diffraction | A, B, C, D | — | — |
| 2O4I | Structure of TREX1 in complex with DNA | x-ray diffraction | A, B | — | — |
| 2O4I | Structure of TREX1 in complex with DNA | x-ray diffraction | A, B | — | — |
| 2OA8 | Crystal Structure of mTREX1 with ssDNA | x-ray diffraction | A, B | — | — |
| 2OA8 | Crystal structure of MTREX1 with ssdna | x-ray diffraction | A, B | — | — |
| 3B6O | Structure of TREX1 in complex with a nucleotide and an inhibitor ion (lithium) | x-ray diffraction | A, B, C, D | — | — |
| 3B6O | Structure of TREX1 in complex with a nucleotide and an inhibitor ion (lithium) | x-ray diffraction | A, B, C, D | — | — |
| 3B6P | Structure of TREX1 in complex with a nucleotide and inhibitor ions (sodium and zinc) | x-ray diffraction | A, B, C, D | — | — |
| 3B6P | Structure of TREX1 in complex with a nucleotide and inhibitor ions (sodium and zinc) | x-ray diffraction | A, B, C, D | — | — |
| 3MXI | TREX1 3' Exonuclease D18N Familial Chilblain Lupus Mutant | x-ray diffraction | B, A | — | — |
| 3MXI | TREX1 3' exonuclease D18N familial chilblain lupus mutant | x-ray diffraction | B, A | — | — |
| 3MXJ | Crystal Structure of the mTREX1 Apoprotein | x-ray diffraction | B, A | — | — |
| 3MXJ | Crystal structure of the MTREX1 apoprotein | x-ray diffraction | B, A | — | — |
| 3MXM | TREX1 3' Exonuclease V201D Aicardi-Goutieres Syndrome Mutant | x-ray diffraction | B, A | — | — |
| 3MXM | TREX1 3' exonuclease V201D aicardi-goutieres syndrome mutant | x-ray diffraction | B, A | — | — |
| 3U3Y | Mouse TREX1 D200H mutant | x-ray diffraction | B, A | — | — |
| 3U3Y | Mouse TREX1 D200H mutant | x-ray diffraction | B, A | — | — |
| 3U6F | Mouse TREX1 D200N mutant | x-ray diffraction | B, A | — | — |
| 3U6F | Mouse TREX1 D200N mutant | x-ray diffraction | B, A | — | — |
| 4YNQ | TREX1-dsDNA complex | x-ray diffraction | A, B, C, D | — | — |
| 4YNQ | TREX1-dsdna complex | x-ray diffraction | A, B, C, D | — | — |
| 5YWS | Crystal structure of TREX1 in complex with a Y structured DNA | x-ray diffraction | A, B | MG | — |
| 5YWS | Crystal structure of TREX1 in complex with a Y structured DNA | x-ray diffraction | A, B | MG | — |
| 5YWT | Crystal structure of TREX1 in complex with a duplex DNA with 3' overhang | x-ray diffraction | A, B | MG, CO | 3 (best 0.59) |
| 5YWT | Crystal structure of TREX1 in complex with a duplex DNA with 3' overhang | x-ray diffraction | A, B | MG, CO | — |
| 5YWU | Crystal structure of TREX1 in complex with a inosine contained dsDNA | x-ray diffraction | A, B | MG | 8 (best 0.67) |
| 5YWU | Crystal structure of TREX1 in complex with a inosine contained dsdna | x-ray diffraction | A, B | MG | — |
| 5YWV | Crystal structure of TREX1 in complex with a inosine contained ssDNA | x-ray diffraction | A, B | MG, NA | 3 (best 0.65) |
| 5YWV | Crystal structure of TREX1 in complex with a inosine contained ssdna | x-ray diffraction | A, B | MG, NA | — |
| 6W10 | Structure of mouse TREX1 with E198K disease-associated mutation | x-ray diffraction | A, B | — | — |
| 7U8Y | TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics | x-ray diffraction | A, B | AZN, MN | 4 (best 0.66) |
| 8HCC | Crystal structure of mTREX1-RNA product complex (AMP) | x-ray diffraction | A, B, C, D | AMP, MG, NA | 9 (best 0.71) |
| 8HCD | Crystal structure of mTREX1-DNA product complex (dNMP) | x-ray diffraction | B, C, D, E | MG, DCM, DGP, CO | 10 (best 0.73) |
| 8HCE | Crystal structure of mTREX1-CMP complex | x-ray diffraction | A, B | SO4, NH4, C5P | 5 (best 0.63) |
| 8HCF | Crystal structure of mTREX1-UMP complex | x-ray diffraction | A, B | SO4, U5P | 5 (best 0.65) |
| 8HCG | Crystal structure of mTREX1-dAMP complex | x-ray diffraction | A | NA, D5M, MG | 3 (best 0.67) |
| 8HCH | Crystal structure of mTREX1-Uridine complex | x-ray diffraction | A, B, C, D | MG, URI | 8 (best 0.64) |
| Q91XB0 | AlphaFold monomer V2.0 prediction for three-prime repair exonuclease 1 (Q91XB0) | — | — | — |
Ligands
- MG · Magnesium ion · in 12 records
- NA · Sodium ion · in 4 records
- CO · Cobalt (II) ion · in 3 records
- SO4 · Sulfate ion · in 2 records
- AMP · Adenosine monophosphate · in 1 record
- AZN · Alizarin red · in 1 record
- C5P · Cytidine-5'-monophosphate · in 1 record
- D5M · 2'-deoxyadenosine-5'-monophosphate · in 1 record
- DCM · 2'-deoxycytidine-5'-monophosphate · in 1 record
- DGP · 2'-deoxyguanosine-5'-monophosphate · in 1 record
- MN · Manganese (II) ion · in 1 record
- NH4 · Ammonium ion · in 1 record
- U5P · Uridine-5'-monophosphate · in 1 record
- URI · Uridine · in 1 record
Elsewhere
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