UniProt Q8IWA4
Mitofusin-1 (Q8IWA4)
Mitofusin-1 (UniProt Q8IWA4), EC 3.6.5.-: 17 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8IWA4
- Protein
- Mitofusin-1
- EC
- 3.6.5.-
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 20 · 4 records with a druggable one
Structures
18 records of Q8IWA4 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GNR | the structure of mini-MFN1 K88A in complex with GDP | x-ray diffraction | A | GDP | 4 (best 0.51) |
| 5GNR | The structure of mini-MFN1 K88A in complex with GDP | x-ray diffraction | A | — | — |
| 5GNS | Structures of human Mitofusin 1 provide insight into mitochondrial tethering | x-ray diffraction | A | GTP | — |
| 5GNS | Structures of human mitofusin 1 provide insight into mitochondrial tethering | x-ray diffraction | A | — | — |
| 5GNT | BDLP-like folding of Mitofusin 1 | x-ray diffraction | A | GDP | — |
| 5GNT | Bdlp-like folding of mitofusin 1 | x-ray diffraction | A | — | — |
| 5GNU | the structure of mini-MFN1 apo | x-ray diffraction | A | — | 3 (best 0.45) |
| 5GNU | The structure of mini-MFN1 apo | x-ray diffraction | A | — | — |
| 5GO4 | Truncated mitofusin-1, nucleotide-free | x-ray diffraction | A | — | 3 (best 0.54) |
| 5GO4 | Truncated mitofusin-1, nucleotide-free | x-ray diffraction | A | — | — |
| 5GOE | Truncated mitofusin-1, GDP-bound | x-ray diffraction | A | GDP | 3 (best 0.51) |
| 5GOE | Truncated mitofusin-1, GDP-bound | x-ray diffraction | A | — | — |
| 5GOF | Truncated mitofusin-1, GTP-bound | x-ray diffraction | A | — | — |
| 5GOM | Truncated mitofusin-1, transition-like state | x-ray diffraction | A, B | GDP | 7 (best 0.82) |
| 5GOM | Truncated mitofusin-1, transition-like state | x-ray diffraction | A, B | — | — |
| 5YEW | Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating… | x-ray diffraction | A, B, C | GDP, BEF, K, MG | — |
| 5YEW | Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating… | x-ray diffraction | A, B, C | GDP, BEF, K, MG | — |
| Q8IWA4 | AlphaFold monomer V2.0 prediction for mitofusin-1 (Q8IWA4) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5GOM chain A against the predicted model Q8IWA4: TM-score 0.98, RMSD 1.12 Å
- 5GOM chain A against the predicted model Q8IWA4: TM-score 0.98, RMSD 1.12 Å
- 5GNT chain A against the predicted model Q8IWA4: TM-score 0.97, RMSD 1.27 Å
- 5GNT chain A against the predicted model Q8IWA4: TM-score 0.97, RMSD 1.27 Å
- 5GNU chain A against the predicted model Q8IWA4: TM-score 0.97, RMSD 1.32 Å
- 5GNU chain A against the predicted model Q8IWA4: TM-score 0.97, RMSD 1.32 Å
- 5GNS chain A against the predicted model Q8IWA4: TM-score 0.97, RMSD 1.34 Å
- 5GNS chain A against the predicted model Q8IWA4: TM-score 0.97, RMSD 1.34 Å
- 5GOE chain A against the predicted model Q8IWA4: TM-score 0.97, RMSD 1.37 Å
- 5GOE chain A against the predicted model Q8IWA4: TM-score 0.97, RMSD 1.37 Å
Elsewhere
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