MolNFT v1 · #120055 · protein

Structures of human mitofusin 1 provide insight into mitochondrial tethering

5GNS · Mitofusin-1: “Structures of human mitofusin 1 provide insight into mitochondrial tethering”. X-ray diffraction, 1 ligand (GTP), 5 pockets (best druggability 0.52). MolNFT v1 #120055 on GenesisL1: 3D structure, binding sites and…

PDB: 5GNS
Type: protein
Length: 377 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitofusin-1
EC: 3.6.5.-
UniProt: Q8IWA4
Ligands: GTP
Pockets: 5 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitofusin-1 (EC 3.6.5.-)	protein	377	55% helix, 12% strand	Q8IWA4

Ligands and binding sites

GTP · Guanosine-5'-triphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	168	0.52	0.79	25	empty
2	82	0.47	0.82	18	empty
3	94	0.35	0.74	21	empty
4	55	0.32	0.77	12	empty
5	56	0.28	0.74	15	empty

Compared structures

5GNS · Structures of human Mitofusin 1 provide insight into mitochondrial tethering · the same entry in another collection · chain A against A, TM-score 1.00
Q8IWA4 · AlphaFold monomer V2.0 prediction for mitofusin-1 (Q8IWA4) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IWA4
Elsewhere: RCSB PDB 5GNS · PDBe 5GNS · UniProt Q8IWA4

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