MolNFT v1 · #120057 · protein

The structure of mini-MFN1 apo

5GNU · Mitofusin-1: “The structure of mini-MFN1 apo”. X-ray diffraction, 3 pockets (best druggability 0.45). MolNFT v1 #120057 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5GNU
Type: protein
Length: 378 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitofusin-1
EC: 3.6.5.-
UniProt: Q8IWA4
Pockets: 3 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitofusin-1 (EC 3.6.5.-)	protein	378	49% helix, 12% strand	Q8IWA4

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.45	0.81	15	empty
2	51	0.36	0.79	15	empty
3	73	0.35	0.76	17	empty

Compared structures

5GNU · the structure of mini-MFN1 apo · the same entry in another collection · chain A against A, TM-score 1.00
Q8IWA4 · AlphaFold monomer V2.0 prediction for mitofusin-1 (Q8IWA4) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IWA4
Elsewhere: RCSB PDB 5GNU · PDBe 5GNU · UniProt Q8IWA4

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