MolNFT v1 · #120076 · protein
Truncated mitofusin-1, GTP-bound
5GOF: “Truncated mitofusin-1, GTP-bound”. X-ray diffraction, 3 ligands (GTP, MG, ZN), 4 pockets (best druggability 0.70). MolNFT v1 #120076 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5GOF
- Type
- protein
- Length
- 390 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitofusin-1
- EC
- 3.6.5.-
- UniProt
- Q8IWA4
- Ligands
- GTP, MG, ZN
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 59% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitofusin-1 (EC 3.6.5.-) | protein | 390 | 59% helix, 12% strand | Q8IWA4 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 292 | 0.70 | 0.84 | 37 | GTP, MG |
| 2 | 65 | 0.32 | 0.75 | 15 | empty |
| 3 | 50 | 0.30 | 0.77 | 14 | empty |
| 4 | 53 | 0.28 | 0.74 | 13 | empty |
Compared structures
- Q8IWA4 · AlphaFold monomer V2.0 prediction for mitofusin-1 (Q8IWA4) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IWA4
- Elsewhere: RCSB PDB 5GOF · PDBe 5GOF · UniProt Q8IWA4
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