UniProt Q5T9L3
Protein wntless homolog (Q5T9L3)
Protein wntless homolog (UniProt Q5T9L3): 8 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 79 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q5T9L3
- Protein
- Protein wntless homolog
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 79 · 7 records with a druggable one
Structures
9 records of Q5T9L3 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7DRT | Human Wntless in complex with Wnt3a | electron microscopy | B | PAM, PCW, CLR, LPE | 13 (best 0.85) |
| 7DRT | Human wntless in complex with WNT3A | electron microscopy | B | PAM, PCW, CLR, LPE | — |
| 7KC4 | Human WLS in complex with WNT8A | electron microscopy | B | NAG, MAN, PLM, DR9, Y01 | 13 (best 0.83) |
| 7KC4 | Human wls in complex with WNT8A | electron microscopy | B | NAG, PLM, DR9, Y01 | — |
| 8TZO | Structure of human Wnt7a bound to WLS and CALR | electron microscopy | B | MAN, PAM, POV | 11 (best 0.83) |
| 8TZP | Structure of human Wnt7a bound to WLS and RECK | electron microscopy | B | PAM, POV | 12 (best 0.83) |
| 8TZR | Structure of human Wnt3a bound to WLS and CALR | electron microscopy | B | MAN, PAM, POV | 11 (best 0.82) |
| 8TZS | Structure of human WLS | electron microscopy | A | — | 10 (best 0.81) |
| Q5T9L3 | AlphaFold monomer V2.0 prediction for protein wntless homolog (Q5T9L3) | predicted | A | — | 9 (best 0.86) |
Ligands
- PAM · Palmitoleic acid · in 5 records
- MAN · alpha-D-mannopyranose · in 3 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 3 records
- CLR · Cholesterol · in 2 records
- DR9 · 1-cis-9-octadecanoyl-2-cis-9-hexadecanoyl phosphatidyl glycerol · in 2 records
- LPE · 1-O-octadecyl-sn-glycero-3-phosphocholine · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 2 records
- PLM · Palmitic acid · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
Experiment against prediction
- 8TZS chain A against the predicted model Q5T9L3: TM-score 0.96, RMSD 1.58 Å
- 8TZO chain B against the predicted model Q5T9L3: TM-score 0.91, RMSD 2.70 Å
- 8TZP chain B against the predicted model Q5T9L3: TM-score 0.91, RMSD 2.72 Å
- 8TZR chain B against the predicted model Q5T9L3: TM-score 0.91, RMSD 2.72 Å
- 7KC4 chain B against the predicted model Q5T9L3: TM-score 0.90, RMSD 2.80 Å
- 7KC4 chain B against the predicted model Q5T9L3: TM-score 0.90, RMSD 2.80 Å
- 7DRT chain B against the predicted model Q5T9L3: TM-score 0.90, RMSD 2.74 Å
- 7DRT chain B against the predicted model Q5T9L3: TM-score 0.90, RMSD 2.74 Å
Elsewhere
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