MolNFT v1 · #499929 · protein

AlphaFold monomer V2.0 prediction for protein wntless homolog (Q5T9L3)

Q5T9L3: “AlphaFold monomer V2.0 prediction for protein wntless homolog (Q5T9L3)”. 9 pockets (best druggability 0.86). MolNFT v1 #499929 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q5T9L3
Type: protein
Length: 541 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x556B5F949095C71590D201CC2FbEA0Ca9e5aD1d7
Molecule: Protein wntless homolog
UniProt: Q5T9L3
Pockets: 9 · best druggability 0.86

Structure

1 distinct chain · 50% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein wntless homolog	protein	541	50% helix, 16% strand	Q5T9L3

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	836	0.86	0.88	88	empty
2	907	0.80	0.82	64	empty
3	207	0.61	0.81	26	empty
4	187	0.57	0.80	20	empty
5	108	0.53	0.83	17	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

8TZS · Structure of human WLS · an experimental structure of the same protein · chain A against A, TM-score 0.86
7DRT · Human wntless in complex with WNT3A · an experimental structure of the same protein · chain A against B, TM-score 0.83
7DRT · Human Wntless in complex with Wnt3a · an experimental structure of the same protein · chain A against B, TM-score 0.83
7KC4 · Human wls in complex with WNT8A · an experimental structure of the same protein · chain A against B, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5T9L3
Elsewhere: UniProt Q5T9L3 · AlphaFold DB Q5T9L3

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