UniProt Q5T848
G-protein coupled receptor 158 (Q5T848)
G-protein coupled receptor 158 (UniProt Q5T848): 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q5T848
- Protein
- G-protein coupled receptor 158
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 20 · 2 records with a druggable one
Structures
10 records of Q5T848 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EWL | cryo-EM structure of apo GPR158 | electron microscopy | A, B | — | — |
| 7EWL | Cryo-EM structure of apo GPR158 | electron microscopy | A, B | — | — |
| 7EWP | Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:1:1 ratio | electron microscopy | A, B | — | — |
| 7EWP | Cryo-EM structure of human GPR158 in complex with RGS7-GBETA5 in a 2:1:1 ratio | electron microscopy | A, B | — | — |
| 7EWR | Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:2:2 ratio | electron microscopy | A, B | — | — |
| 7EWR | Cryo-EM structure of human GPR158 in complex with RGS7-GBETA5 in a 2:2:2 ratio | electron microscopy | A, B | — | — |
| 7SHE | Cryo-EM structure of human GPR158 | electron microscopy | A, B | PEE, EIJ, CLR | — |
| 7SHF | Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex | electron microscopy | B, A | CLR, EIJ, PEE | 10 (best 0.80) |
| 7SHF | Cryo-EM structure of GPR158 coupled to the RGS7-GBETA5 complex | electron microscopy | B, A | CLR, EIJ, PEE | — |
| Q5T848 | AlphaFold monomer V2.0 prediction for probable G-protein coupled receptor 158 (Q5T848) | predicted | A | — | 10 (best 0.77) |
Ligands
Experiment against prediction
- 7SHF chain B against the predicted model Q5T848: TM-score 0.90, RMSD 1.31 Å
- 7SHF chain B against the predicted model Q5T848: TM-score 0.90, RMSD 1.31 Å
- 7SHF chain A against the predicted model Q5T848: TM-score 0.86, RMSD 1.85 Å
- 7SHF chain A against the predicted model Q5T848: TM-score 0.86, RMSD 1.85 Å
- 7EWL chain B against the predicted model Q5T848: TM-score 0.85, RMSD 3.56 Å
- 7EWL chain B against the predicted model Q5T848: TM-score 0.85, RMSD 3.56 Å
- 7EWL chain A against the predicted model Q5T848: TM-score 0.84, RMSD 3.51 Å
- 7EWL chain A against the predicted model Q5T848: TM-score 0.84, RMSD 3.51 Å
- 7EWP chain B against the predicted model Q5T848: TM-score 0.83, RMSD 3.83 Å
- 7EWR chain B against the predicted model Q5T848: TM-score 0.83, RMSD 3.83 Å
Elsewhere
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