MolNFT v1 · #187503 · protein

Cryo-EM structure of human GPR158

7SHE: “Cryo-EM structure of human GPR158”. Electron microscopy, 3 ligands (CLR, PEE, EIJ). MolNFT v1 #187503 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7SHE
Type: protein
Length: 1,081 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q5T848
Ligands: CLR, PEE, EIJ

Structure

electron microscopy · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	541	—	Q5T848
B	—	protein	540	—	Q5T848

Ligands and binding sites

CLR · Cholesterol · ligand · 22 copies · chains A, B
PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · ligand · chains A, B
EIJ · (2S)-1-{[(S)-hydroxy{[(1s,2r,3r,4r,5s,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5, 8,11,14-tetraenoate · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7SHE · Cryo-EM structure of human GPR158 · the same entry in another collection · chain A against A, TM-score 1.00
Q5T848 · AlphaFold monomer V2.0 prediction for probable G-protein coupled receptor 158 (Q5T848) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5T848
Elsewhere: RCSB PDB 7SHE · PDBe 7SHE · UniProt Q5T848

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