EIJ · (2S)-1-{[(S)-hydroxy{[(1s,2r,3r,4r,5s,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5, 8,11,14-tetraenoate

Binding sites

EIJ in 3 structures; the first of them:

• 7SHF · Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex · EIJ A813 · binds LEU489, PHE492, ALA493, ARG525, MET529, VAL532, ILE533, LEU535 and 18 more
• 7SHE · Cryo-EM structure of human GPR158 · EIJ A802 · binds LEU489, HIS504, LYS508, MET529, VAL536, PHE540, THR582, PHE589 and 11 more
• 7SHF · Cryo-EM structure of GPR158 coupled to the RGS7-GBETA5 complex · EIJ A813 · binds LEU489, PHE492, ARG525, MET529, VAL532, ILE533, LEU535, VAL536 and 10 more

Residues it binds most

LEU 3, VAL 3, PHE 3, MET 3, TRP 3, ALA 3, ARG 3, ILE 3, LYS 3, GLU 2 (residue and the binding sites it lines).

Found with

• CLR · Cholesterol
• PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine