MolNFT v1 · #177870 · protein
Cryo-EM structure of apo GPR158
7EWL · Probable G-protein coupled receptor 158: “Cryo-EM structure of apo GPR158”. Electron microscopy, 16 pockets (best druggability 0.79). MolNFT v1 #177870 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EWL
- Type
- protein
- Length
- 994 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable G-protein coupled receptor 158
- UniProt
- Q5T848
- Pockets
- 16 · best druggability 0.79
Structure
electron microscopy · 2 distinct chains · 46% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable G-protein coupled receptor 158 | protein | 499 | 47% helix, 13% strand | Q5T848 |
| B | Probable G-protein coupled receptor 158 | protein | 495 | 45% helix, 12% strand | Q5T848 |
Pockets
16 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1126 | 0.79 | 0.80 | 52 | empty |
| 2 | 95 | 0.76 | 0.97 | 23 | empty |
| 3 | 646 | 0.74 | 0.81 | 82 | empty |
| 4 | 776 | 0.73 | 0.78 | 84 | empty |
| 5 | 71 | 0.72 | 0.96 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1808 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5T848
- Elsewhere: RCSB PDB 7EWL · PDBe 7EWL · UniProt Q5T848
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.