UniProt Q13257
Mitotic spindle assembly checkpoint protein MAD2A (Q13257)
Mitotic spindle assembly checkpoint protein MAD2A (UniProt Q13257): 24 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13257
- Protein
- Mitotic spindle assembly checkpoint protein MAD2A
- Experimental structures
- 24
- Predicted models
- 1
- Pockets
- 5 · 3 records with a druggable one
Structures
25 records of Q13257 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DUJ | Solution structure of the spindle assembly checkpoint protein human MAD2 | solution nmr | A | — | — |
| 1DUJ | Solution structure of the spindle assembly checkpoint protein human MAD2 | solution nmr | A | — | — |
| 1GO4 | Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20. | x-ray diffraction | A, B, C, D | — | — |
| 1GO4 | Crystal structure of MAD1-MAD2 reveals a conserved MAD2 binding motif in MAD1 and CDC20. | x-ray diffraction | A, B, C, D | — | — |
| 1KLQ | The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon Binding to… | solution nmr | A | — | — |
| 1KLQ | The MAD2 spindle checkpoint protein undergoes similar major conformational changes upon binding to… | solution nmr | A | — | — |
| 1S2H | The Mad2 spindle checkpoint protein possesses two distinct natively folded states | solution nmr | A | — | — |
| 1S2H | The MAD2 spindle checkpoint protein possesses two distinct natively folded states | solution nmr | A | — | — |
| 2QYF | Crystal structure of the Mad2/p31(comet)/Mad2-binding peptide ternary complex | x-ray diffraction | A, C | — | — |
| 2QYF | Crystal structure of the MAD2/P31(COMET)/MAD2-binding peptide ternary complex | x-ray diffraction | A, C | — | — |
| 2V64 | Crystallographic structure of the conformational dimer of the Spindle Assembly Checkpoint protein… | x-ray diffraction | A, C, D, E, F, H | — | — |
| 2V64 | Crystallographic structure of the conformational dimer of the spindle assembly checkpoint protein… | x-ray diffraction | A, C, D, E, F, H | — | — |
| 2VFX | Structure of the Symmetric Mad2 Dimer | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 2VFX | Structure of the symmetric MAD2 dimer | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3GMH | Crystal Structure of the Mad2 Dimer | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3GMH | Crystal structure of the MAD2 dimer | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 5KHU | Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the… | electron microscopy | T | — | — |
| 5KHU | Model of human anaphase-promoting COMPLEX/CYCLOSOME (APC15 deletion mutant), in complex with the… | electron microscopy | T | — | — |
| 5LCW | Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic… | electron microscopy | Z | — | 1 (best 0.81) |
| 5LCW | Cryo-EM structure of the anaphase-promoting COMPLEX/CYCLOSOME, in complex with the mitotic… | electron microscopy | Z | — | — |
| 6F0X | Cryo-EM structure of TRIP13 in complex with ATP gamma S, p31comet, C-Mad2 and Cdc20 | electron microscopy | Z | — | 3 (best 0.67) |
| 6F0X | Cryo-EM structure of TRIP13 in complex with ATP gamma S, P31COMET, C- MAD2 and CDC20 | electron microscopy | Z | — | — |
| 6TLJ | Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic… | electron microscopy | Z | — | 1 (best 0.87) |
| 6TLJ | Cryo-EM structure of the anaphase-promoting COMPLEX/CYCLOSOME, in complex with the mitotic… | electron microscopy | Z | — | — |
| Q13257 | AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2A (Q13257) | predicted | A | — | — |
Experiment against prediction
- 2VFX chain E against the predicted model Q13257: TM-score 0.98, RMSD 0.61 Å
- 2VFX chain E against the predicted model Q13257: TM-score 0.98, RMSD 0.61 Å
- 2VFX chain A against the predicted model Q13257: TM-score 0.99, RMSD 0.47 Å
- 2VFX chain A against the predicted model Q13257: TM-score 0.99, RMSD 0.47 Å
- 2VFX chain G against the predicted model Q13257: TM-score 0.99, RMSD 0.52 Å
- 2VFX chain G against the predicted model Q13257: TM-score 0.99, RMSD 0.52 Å
- 2VFX chain J against the predicted model Q13257: TM-score 0.98, RMSD 0.64 Å
- 2VFX chain J against the predicted model Q13257: TM-score 0.98, RMSD 0.64 Å
- 2VFX chain D against the predicted model Q13257: TM-score 0.98, RMSD 0.68 Å
- 2VFX chain D against the predicted model Q13257: TM-score 0.98, RMSD 0.68 Å
Elsewhere
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