MolNFT v1 · #12595 · protein

The MAD2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either MAD1 or CDC20

1KLQ · Mitotic spindle assembly checkpoint protein MAD2A: “The MAD2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either…”. Solution nmr, 1 pocket (best druggability 0.40). MolNFT v1 #12595 on…

PDB: 1KLQ
Type: protein
Length: 207 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitotic spindle assembly checkpoint protein MAD2A; MAD2-binding peptide
UniProt: Q13257
Pockets: 1 · best druggability 0.40

Structure

solution nmr · 2 distinct chains · 31% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitotic spindle assembly checkpoint protein MAD2A	protein	197	32% helix, 31% strand	Q13257
B	MAD2-binding peptide	protein	10	0% helix, 40% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.40	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 745 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

1KLQ · The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon… · the same entry in another collection · chain A against A, TM-score 1.00
Q13257 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2A… · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13257
Elsewhere: RCSB PDB 1KLQ · PDBe 1KLQ · UniProt Q13257

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