Research workbench
The MAD2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either MAD1 or CDC20
Analyse The MAD2 spindle checkpoint protein undergoes similar major conformational… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1KLQ
- Type
- protein
- Length
- 207 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitotic spindle assembly checkpoint protein MAD2A; MAD2-binding peptide
- UniProt
- Q13257
- Pockets
- 1 · best druggability 0.40
Structure
solution nmr · 2 distinct chains · 31% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitotic spindle assembly checkpoint protein MAD2A | protein | 197 | 32% helix, 31% strand | Q13257 |
| B | MAD2-binding peptide | protein | 10 | 0% helix, 40% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 96 | 0.40 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 745 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 1KLQ · The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon… · the same entry in another collection · chain A against A, TM-score 1.00
- Q13257 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2A… · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13257
- Elsewhere: RCSB PDB 1KLQ · PDBe 1KLQ · UniProt Q13257
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