MolNFT v1 · #21194 · protein

The MAD2 spindle checkpoint protein possesses two distinct natively folded states

1S2H · Mitotic spindle assembly checkpoint protein MAD2A: “The MAD2 spindle checkpoint protein possesses two distinct natively folded states”. Solution nmr, 5 pockets (best druggability 0.47). MolNFT v1 #21194 on GenesisL1: 3D structure…

PDB: 1S2H
Type: protein
Length: 205 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitotic spindle assembly checkpoint protein MAD2A
UniProt: Q13257
Pockets: 5 · best druggability 0.47

Structure

solution nmr · 1 distinct chain · 32% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitotic spindle assembly checkpoint protein MAD2A	protein	205	32% helix, 29% strand	Q13257

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	124	0.47	0.78	25	empty
2	96	0.39	0.76	17	empty
3	85	0.39	0.77	15	empty
4	88	0.33	0.73	19	empty
5	79	0.32	0.74	18	empty

Compared structures

1S2H · The Mad2 spindle checkpoint protein possesses two distinct natively folded states · the same entry in another collection · chain A against A, TM-score 1.00
Q13257 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2A… · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13257
Elsewhere: RCSB PDB 1S2H · PDBe 1S2H · UniProt Q13257

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