UniProt Q07889
Son of sevenless homolog 1 (Q07889)
Son of sevenless homolog 1 (UniProt Q07889): 142 experimental structures and 1 predicted model on GenesisL1, 52 ligands bound, 306 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q07889
- Protein
- Son of sevenless homolog 1
- Experimental structures
- 142
- Predicted models
- 1
- Ligands
- 52
- Pockets
- 306 · 26 records with a druggable one
Structures
143 records of Q07889 in the MolNFT archive: 142 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AWE | Human SOS1 pleckstrin homology (pH) domain, NMR, 20 structures | solution nmr | A | — | — |
| 1AWE | Human SOS1 pleckstrin homology (pH) domain, NMR, 20 structures | solution nmr | A | — | — |
| 1BKD | Complex of human H-RAS with human sos-1 | x-ray diffraction | S | — | — |
| 1BKD | Complex of human H-RAS with human sos-1 | x-ray diffraction | S | — | — |
| 1DBH | Dbl and pleckstrin homology domains from HSOS1 | x-ray diffraction | A | — | — |
| 1DBH | Dbl and pleckstrin homology domains from HSOS1 | x-ray diffraction | A | — | — |
| 1NVU | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange… | x-ray diffraction | S | — | — |
| 1NVU | Structural evidence for feedback activation by rasgtp of the RAS- specific nucleotide exchange… | x-ray diffraction | S | — | — |
| 1NVV | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange… | x-ray diffraction | S | — | — |
| 1NVV | Structural evidence for feedback activation by rasgtp of the RAS- specific nucleotide exchange… | x-ray diffraction | S | — | — |
| 1NVW | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange… | x-ray diffraction | S | — | — |
| 1NVW | Structural evidence for feedback activation by rasgtp of the RAS-specific nucleotide exchange… | x-ray diffraction | S | — | — |
| 1NVX | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange… | x-ray diffraction | S | — | — |
| 1NVX | Structural evidence for feedback activation by rasgtp of the RAS- specific nucleotide exchange… | x-ray diffraction | S | — | — |
| 1Q9C | Crystal Structure of the Histone domain of Son of Sevenless | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 1Q9C | Crystal structure of the histone domain of son of sevenless | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 1XD2 | Crystal Structure of a ternary Ras:SOS:Ras*GDP complex | x-ray diffraction | C | — | — |
| 1XD2 | Crystal structure of a ternary RAS:SOS:RAS*GDP complex | x-ray diffraction | C | — | — |
| 1XD4 | Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) | x-ray diffraction | A, B | — | — |
| 1XD4 | Crystal structure of the dh-pH-cat module of son of sevenless (sos) | x-ray diffraction | A, B | — | — |
| 1XDV | Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. | x-ray diffraction | A, B | — | — |
| 1XDV | Experimentally phased structure of human the son of sevenless protein at 4.1 ang. | x-ray diffraction | A, B | — | — |
| 2II0 | Crystal Structure of catalytic domain of Son of sevenless (Rem-Cdc25) in the absence of Ras | x-ray diffraction | A | — | — |
| 2II0 | Crystal structure of catalytic domain of son of sevenless (rem-CDC25) in the absence of RAS | x-ray diffraction | A | — | — |
| 3KSY | Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras activator Son of… | x-ray diffraction | A | — | — |
| 3KSY | Crystal structure of the histone domain, dh-pH unit, and catalytic unit of the RAS activator son of… | x-ray diffraction | A | — | — |
| 4NYI | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | x-ray diffraction | S | — | — |
| 4NYI | Approach for targeting RAS with small molecules that activate sos- mediated nucleotide exchange | x-ray diffraction | S | — | — |
| 4NYJ | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | x-ray diffraction | S | — | — |
| 4NYJ | Approach for targeting RAS with small molecules that activate sos- mediated nucleotide exchange | x-ray diffraction | S | — | — |
| 4NYM | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | x-ray diffraction | S | — | — |
| 4NYM | Approach for targeting RAS with small molecules that activate sos- mediated nucleotide exchange | x-ray diffraction | S | — | — |
| 4URU | The crystal structure of H-Ras and SOS in complex with ligands | x-ray diffraction | S | — | — |
| 4URU | The crystal structure of H-RAS and sos in complex with ligands | x-ray diffraction | S | — | — |
| 4URV | The crystal structure of H-Ras and SOS in complex with ligands | x-ray diffraction | S | — | — |
| 4URV | The crystal structure of H-RAS and sos in complex with ligands | x-ray diffraction | S | — | — |
| 4URW | The crystal structure of H-Ras and SOS in complex with ligands | x-ray diffraction | S | — | — |
| 4URW | The crystal structure of H-RAS and sos in complex with ligands | x-ray diffraction | S | — | — |
| 4URX | The crystal structure of H-Ras and SOS in complex with ligands | x-ray diffraction | S | — | — |
| 4URX | The crystal structure of H-RAS and sos in complex with ligands | x-ray diffraction | S | — | — |
| 4URY | The crystal structure of H-Ras and SOS in complex with ligands | x-ray diffraction | S | — | — |
| 4URY | The crystal structure of H-RAS and sos in complex with ligands | x-ray diffraction | S | — | — |
| 4URZ | The crystal structure of H-Ras and SOS in complex with ligands | x-ray diffraction | S | — | — |
| 4URZ | The crystal structure of H-RAS and sos in complex with ligands | x-ray diffraction | S | — | — |
| 4US0 | The crystal structure of H-Ras and SOS in complex with ligands | x-ray diffraction | S | — | — |
| 4US0 | The crystal structure of H-RAS and sos in complex with ligands | x-ray diffraction | S | — | — |
| 4US1 | The crystal structure of H-Ras and SOS in complex with ligands | x-ray diffraction | S | — | — |
| 4US1 | The crystal structure of H-RAS and sos in complex with ligands | x-ray diffraction | S | — | — |
| 4US2 | The crystal structure of H-Ras and SOS in complex with ligands | x-ray diffraction | S | — | — |
| 4US2 | The crystal structure of H-RAS and sos in complex with ligands | x-ray diffraction | S | — | — |
| 5OVD | RAS guanine nucleotide exchange factor SOS1 (rem-CDC25) in new crystal form | x-ray diffraction | A | — | — |
| 5OVE | Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor… | x-ray diffraction | A | AXE | 6 (best 0.42) |
| 5OVE | RAS guanine nucleotide exchange factor SOS1 (rem-CDC25) in complex with small molecule inhibitor… | x-ray diffraction | A | AXE | — |
| 5OVF | Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor… | x-ray diffraction | A | AWT | 7 (best 0.44) |
| 5OVF | RAS guanine nucleotide exchange factor SOS1 (rem-CDC25) in complex with small molecule inhibitor… | x-ray diffraction | A | AWT | — |
| 5OVG | Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor… | x-ray diffraction | A | AWZ | 6 (best 0.41) |
| 5OVG | RAS guanine nucleotide exchange factor SOS1 (rem-CDC25) in complex with small molecule inhibitor… | x-ray diffraction | A | AWZ | — |
| 5OVH | RAS guanine nucleotide exchange factor SOS1 (rem-CDC25) in complex with small molecule inhibitor… | x-ray diffraction | A | AWW | — |
| 5OVI | Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor… | x-ray diffraction | A | AXH | 6 (best 0.54) |
| 5OVI | RAS guanine nucleotide exchange factor SOS1 (rem-CDC25) in complex with small molecule inhibitor… | x-ray diffraction | A | AXH | — |
83 records more on the page itself.
Ligands
- CL · Chloride ion · in 4 records
- 5UU · 6-chloranyl-~{N}-(4-fluorophenyl)-1,2,3,4-tetrahydroacridin-9-amine · in 2 records
- 5UV · 7-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2, 3,4-tetrahydroacridin-9-amine · in 2 records
- 5UW · ~{N}-(3,3-diphenylpropyl)piperidin-4-amine · in 2 records
- 5UX · 6-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2, 3,4-tetrahydroacridin-9-amine · in 2 records
- AWT · 6,7-dimethoxy-2-methyl-~{N}-[(1~{R})-1-[3-(1~{H}-pyrazol-4-yl)phenyl]ethyl]quinazolin-4-amine · in 2 records
- AWZ · ~{N}-[(1~{R})-1-[5-(6,7-dihydro-5~{H}-pyrrolo[1,2-a]imidazol-3-yl)thiophen-2-yl]ethyl]-6,7-dimethoxy-2-methyl-quinazolin-4-amine · in 2 records
- AXE · 6,7-dimethoxy-~{N}-[(1~{R})-1-naphthalen-1-ylethyl]quinazolin-4-amine · in 2 records
- AXH · 6,7-dimethoxy-2-methyl-~{N}-[(1~{R})-1-[4-[2-(methylaminomethyl)phenyl]thiophen-2-yl]ethyl]quinazolin-4-amine · in 2 records
- BOQ · ethyl 2-(aminomethyl)-5-~{tert}-butyl-furan-3-carboxylate · in 2 records
- BQ2 · 1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-ethanone · in 2 records
- EAS · 5-chloro-N-{1-[(5-chloro-1H-indol-3-yl) methyl]piperidin-4-yl}-L-tryptophanamide · in 2 records
- EBY · N-{1-[(5-chloro-1H-indol-3-yl)methyl]piperidin-4-yl}-5-methyl-L-tryptophanamide · in 2 records
- EC4 · 6-chloro-N-{1-[(5-chloro-1H-indol-3-yl) methyl]piperidin-4-yl}-L-tryptophanamide · in 2 records
- FFV · N~2~-(3-chloro-4-fluorophenyl)-N~4~-[(1R)-1-cyclopropylethyl]quinazoline-2,4-diamine · in 2 records
- FFY · N~2~-(3-chloro-4-fluorophenyl)-N~4~-[(1R)-1-cyclopropylethyl]-8-(1,2,3,6-tetrahydropyridin-4-yl) quinazoline-2,4-diamine · in 2 records
- FV7 · 6-chloro-4-(2-chlorophenyl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazole · in 2 records
- FVM · 6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-4-(3,5-dimethyl-1H-pyrazol-4-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-1H-benzimidazole · in 2 records
- FW4 · 1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethyl-2-(piperazin-1-yl)-1H-benzimidazole · in 2 records
- FW7 · 6-chloro-1-[(3-chloro-4-fluorophenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazole · in 2 records
- L7H · ~{N}-[(1~{R})-1-[3-azanyl-5-(trifluoromethyl) phenyl]ethyl]-7-methoxy-2-methyl-6-[(3~{S})-oxolan-3-yl]oxy-quinazolin-4-amine · in 2 records
- LBK · 6,7-dimethoxy-~{N}-[(1~{R})-1-phenylethyl]quinazolin-4-amine · in 2 records
- NKF · 2-methyl-3-[(1R)-1-{[4-methyl-7-(morpholin-4-yl) pyrido[3,4-d]pyridazin-1-yl]amino}ethyl]benzonitrile · in 2 records
- QTD · 4-phenoxybenzene-1-sulfonamide · in 2 records
- QTS · 1-[(4-chlorophenyl)methyl]-1H-benzimidazol-2-amine · in 2 records
- QTV · 1-[(4-fluorophenyl)methyl]-2-methyl-4-nitro-1H-imidazole · in 2 records
- S2Q · 3-propan-2-yl-~{N}-[(1~{R})-1-(3-sulfamoylphenyl) ethyl]-[1,2]oxazolo[5,4-b]pyridine-5-carboxamide · in 2 records
- S2W · ~{N}-[(1~{R})-1-[3-azanyl-5-(trifluoromethyl) phenyl]ethyl]-2-methyl-quinazolin-4-amine · in 2 records
- S2Z · 6,7-dimethoxy-2-methyl-~{N}-[(1~{R})-1-phenylethyl]quinazolin-4-amine · in 2 records
- S3T · ~{N}-[(1~{R})-1-(3-aminophenyl)ethyl]-6,7-dimethoxy-2-methyl-quinazolin-4-amine · in 2 records
Experiment against prediction
- 7UKR chain A against the predicted model Q07889: TM-score 0.99, RMSD 0.88 Å
- 7UKR chain B against the predicted model Q07889: TM-score 0.99, RMSD 0.89 Å
- 1Q9C chain C against the predicted model Q07889: TM-score 0.99, RMSD 0.58 Å
- 1Q9C chain C against the predicted model Q07889: TM-score 0.99, RMSD 0.58 Å
- 1Q9C chain A against the predicted model Q07889: TM-score 0.98, RMSD 0.67 Å
- 1Q9C chain A against the predicted model Q07889: TM-score 0.98, RMSD 0.67 Å
- 1Q9C chain B against the predicted model Q07889: TM-score 0.98, RMSD 0.85 Å
- 1Q9C chain B against the predicted model Q07889: TM-score 0.98, RMSD 0.85 Å
- 1Q9C chain G against the predicted model Q07889: TM-score 0.97, RMSD 1.01 Å
- 1Q9C chain G against the predicted model Q07889: TM-score 0.97, RMSD 1.01 Å
Elsewhere
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