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Ligand · AWT

AWT · 6,7-dimethoxy-2-methyl-~{N}-[(1~{R})-1-[3-(1~{H}-pyrazol-4-yl)phenyl]ethyl]quinazolin-4-amine

AWT, 6,7-dimethoxy-2-methyl-~{N}-[(1~{R})-1-[3-(1~{H}-pyrazol-4-yl)phenyl]ethyl]quinazolin-4-amine (C22 H23 N5 O2, 389.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
AWT
Formula
C22 H23 N5 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

AWT in 2 structures; the first of them:

  • 5OVF · Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule… · AWT A1101 · binds VAL875, MET878, ASN879, TYR884, PHE890, LYS898, LEU901, GLU902 and 2 more
  • 5OVF · RAS guanine nucleotide exchange factor SOS1 (rem-CDC25) in complex with small molecule… · AWT A1101 · binds MET878, ASN879, TYR884, PHE890, LYS898, LEU901, GLU902, HIS905 and 1 more

Residues it binds most

GLU 2, ASN 2, HIS 2, LEU 2, LYS 2, MET 2, PHE 2, TYR 2, VAL 1 (residue and the binding sites it lines).

Found with

  • EDO · 1,2-ethanediol

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