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Ligand · EC4

EC4 · 6-chloro-N-{1-[(5-chloro-1H-indol-3-yl) methyl]piperidin-4-yl}-L-tryptophanamide

EC4, 6-chloro-N-{1-[(5-chloro-1H-indol-3-yl) methyl]piperidin-4-yl}-L-tryptophanamide (C25 H27 Cl2 N5 O, 484.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5…

Component
EC4
Formula
C25 H27 Cl2 N5 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

EC4 in 2 structures; the first of them:

  • 6BVI · Ras:SOS:Ras in complex with a small molecule activator · EC4 B2001 · binds MET878, ASN879, TYR884, ASP887, PHE890, GLU891, LYS898, LEU901 and 2 more
  • 6BVI · RAS:SOS:RAS in complex with a small molecule activator · EC4 B2001 · binds MET878, ASN879, TYR884, ASP887, PHE890, LYS898, LEU901, GLU902 and 1 more

Residues it binds most

GLU 2, ASN 2, ASP 2, HIS 2, LEU 2, LYS 2, MET 2, PHE 2, TYR 2 (residue and the binding sites it lines).

Found with

  • GNP · Phosphoaminophosphonic acid-guanylate ester
  • MG · Magnesium ion
  • NA · Sodium ion
  • FMT · Formic acid
  • GOL · Glycerol

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