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Ligand · FFV

FFV · N~2~-(3-chloro-4-fluorophenyl)-N~4~-[(1R)-1-cyclopropylethyl]quinazoline-2,4-diamine

FFV, N~2~-(3-chloro-4-fluorophenyl)-N~4~-[(1R)-1-cyclopropylethyl]quinazoline-2,4-diamine (C19 H18 Cl F N4, 356.8 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within…

Component
FFV
Formula
C19 H18 Cl F N4
Class
ligand
Structures
2
PDB entries
1

Binding sites

FFV in 2 structures; the first of them:

  • 6CUP · Ras:SOS:Ras in complex with a small molecule activator · FFV B2001 · binds VAL852, MET878, ASN879, VAL883, TYR884, LEU886, THR889, PHE890 and 3 more
  • 6CUP · RAS:SOS:RAS in complex with a small molecule activator · FFV B2001 · binds VAL852, MET878, ASN879, VAL883, TYR884, LEU886, THR889, PHE890 and 3 more

Residues it binds most

LEU 2, VAL 2, ASN 2, GLU 2, HIS 2, MET 2, PHE 2, THR 2, TYR 2 (residue and the binding sites it lines).

Found with

  • GNP · Phosphoaminophosphonic acid-guanylate ester
  • MG · Magnesium ion
  • NA · Sodium ion
  • FMT · Formic acid
  • GOL · Glycerol

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